OTX1


OTX1
Orthodenticle homeobox 1
Identifiers
Symbols OTX1; FLJ38361; MGC15736
External IDs OMIM600036 MGI97450 HomoloGene7875 GeneCards: OTX1 Gene
Orthologs
Species Human Mouse
Entrez 5013 18423
Ensembl ENSG00000115507 ENSMUSG00000005917
UniProt P32242 Q3TYJ4
RefSeq (mRNA) NM_001199770.1 NM_011023.3
RefSeq (protein) NP_001186699.1 NP_035153.1
Location (UCSC) Chr 2:
63.28 – 63.28 Mb
Chr 11:
21.89 – 21.9 Mb
PubMed search [1] [2]

Homeobox protein OTX1 is a protein that in humans is encoded by the OTX1 gene.[1][2]

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. The Otx gene is active in the region of the first gill arch, which is related to the upper and lower jaw and two of the bones of the ear.[3] A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy.[2]

References

  1. ^ Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E (Dec 1994). "Chromosome locations of human EMX and OTX genes". Genomics 22 (1): 41–5. doi:10.1006/geno.1994.1343. PMID 7959790. 
  2. ^ a b "Entrez Gene: OTX1 orthodenticle homeobox 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5013. 
  3. ^ Shubin, Neil "Your Inner Fish" 2009

Further reading

External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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