WT1


WT1

Wilms tumor 1, also known as WT1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms.
[cite web | title = Entrez Gene: WT1 Wilms tumor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7490| accessdate = ]

The WT1 protein has been found to bind a host of cellular factors, e.g. p53, a known tumor suppressor.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Haber DA, Buckler AJ |title=WT1: a novel tumor suppressor gene inactivated in Wilms' tumor. |journal=New Biol. |volume=4 |issue= 2 |pages= 97–106 |year= 1992 |pmid= 1313285 |doi=
*cite journal | author=Rauscher FJ |title=The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor. |journal=FASEB J. |volume=7 |issue= 10 |pages= 896–903 |year= 1993 |pmid= 8393820 |doi=
*cite journal | author=Lee SB, Haber DA |title=Wilms tumor and the WT1 gene. |journal=Exp. Cell Res. |volume=264 |issue= 1 |pages= 74–99 |year= 2001 |pmid= 11237525 |doi= 10.1006/excr.2000.5131
*cite journal | author=Scharnhorst V, van der Eb AJ, Jochemsen AG |title=WT1 proteins: functions in growth and differentiation. |journal=Gene |volume=273 |issue= 2 |pages= 141–61 |year= 2001 |pmid= 11595161 |doi=
*cite journal | author=Lim HN, Hughes IA, Hawkins JR |title=Clinical and molecular evidence for the role of androgens and WT1 in testis descent. |journal=Mol. Cell. Endocrinol. |volume=185 |issue= 1-2 |pages= 43–50 |year= 2003 |pmid= 11738793 |doi=
*cite journal | author=Heathcott RW, Morison IM, Gubler MC, "et al." |title=A review of the phenotypic variation due to the Denys-Drash syndrome-associated germline WT1 mutation R362X. |journal=Hum. Mutat. |volume=19 |issue= 4 |pages= 462 |year= 2002 |pmid= 11933209 |doi= 10.1002/humu.9031
*cite journal | author=Wagner KD, Wagner N, Schedl A |title=The complex life of WT1. |journal=J. Cell. Sci. |volume=116 |issue= Pt 9 |pages= 1653–8 |year= 2004 |pmid= 12665546 |doi=
*cite journal | author=Amini Nik S, Hohenstein P |title=Upregulation of Wilms' tumor gene 1 (WT1) in desmoid tumors. |journal=Int J Cancer |volume=114 |issue=2 |pages= 202-8 |year= 2005 |pmid= 15540161 |doi=
*cite journal | author=Niaudet P, Gubler MC |title=WT1 and glomerular diseases. |journal=Pediatr. Nephrol. |volume=21 |issue= 11 |pages= 1653–60 |year= 2007 |pmid= 16927106 |doi= 10.1007/s00467-006-0208-1
*cite journal | author=Coosemans A, Amini Nik S |title=Upregulation of Wilms' tumour gene 1 (WT1) in uterine sarcomas. |journal=Eur J Cancer |volume=43 |issue= 10 |pages= 1630–37 |year= 2007 |pmid= 17531467 |doi=
*cite journal | author=Hohenstein P, Hastie ND |title=The many facets of the Wilms' tumour gene, WT1. |journal=Hum. Mol. Genet. |volume=15 Spec No 2 |issue= |pages= R196–201 |year= 2006 |pmid= 16987884 |doi= 10.1093/hmg/ddl196

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