CAMP responsive element binding protein 3, also known as CREB3, is a human gene.cite web | title = Entrez Gene: CREB3 cAMP responsive element binding protein 3| url =| accessdate = ]

section_title =
summary_text = This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.cite web | title = Entrez Gene: CREB3 cAMP responsive element binding protein 3| url =| accessdate = ]

ee also



Further reading

citations =
*cite journal | author=Lu R, Yang P, O'Hare P, Misra V |title=Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor. |journal=Mol. Cell. Biol. |volume=17 |issue= 9 |pages= 5117–26 |year= 1997 |pmid= 9271389 |doi=
*cite journal | author=Freiman RN, Herr W |title=Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP. |journal=Genes Dev. |volume=11 |issue= 23 |pages= 3122–7 |year= 1998 |pmid= 9389645 |doi=
*cite journal | author=Lu R, Yang P, Padmakumar S, Misra V |title=The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF. |journal=J. Virol. |volume=72 |issue= 8 |pages= 6291–7 |year= 1998 |pmid= 9658067 |doi=
*cite journal | author=Lu R, Misra V |title=Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency. |journal=J. Virol. |volume=74 |issue= 2 |pages= 934–43 |year= 2000 |pmid= 10623756 |doi=
*cite journal | author=Mahajan SS, Wilson AC |title=Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 919–28 |year= 2000 |pmid= 10629049 |doi=
*cite journal | author=Jin DY, Wang HL, Zhou Y, "et al." |title=Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation. |journal=EMBO J. |volume=19 |issue= 4 |pages= 729–40 |year= 2000 |pmid= 10675342 |doi= 10.1093/emboj/19.4.729
*cite journal | author=Luciano RL, Wilson AC |title=N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 20 |pages= 10757–62 |year= 2000 |pmid= 10984507 |doi= 10.1073/pnas.190062797
*cite journal | author=Raggo C, Rapin N, Stirling J, "et al." |title=Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis. |journal=Mol. Cell. Biol. |volume=22 |issue= 16 |pages= 5639–49 |year= 2002 |pmid= 12138176 |doi=
*cite journal | author=Mahajan SS, Little MM, Vazquez R, Wilson AC |title=Interaction of HCF-1 with a cellular nuclear export factor. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44292–9 |year= 2003 |pmid= 12235138 |doi= 10.1074/jbc.M205440200
*cite journal | author=Luciano RL, Wilson AC |title=An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13403–8 |year= 2002 |pmid= 12271126 |doi= 10.1073/pnas.202200399
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ko J, Jang SW, Kim YS, "et al." |title=Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. |journal=FASEB J. |volume=18 |issue= 7 |pages= 890–2 |year= 2004 |pmid= 15001559 |doi= 10.1096/fj.03-0867fje
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Misra V, Rapin N, Akhova O, "et al." |title=Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 15257–66 |year= 2005 |pmid= 15705566 |doi= 10.1074/jbc.M500728200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Liang G, Audas TE, Li Y, "et al." |title=Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. |journal=Mol. Cell. Biol. |volume=26 |issue= 21 |pages= 7999–8010 |year= 2007 |pmid= 16940180 |doi= 10.1128/MCB.01046-06
*cite journal | author=Blot G, Lopez-Vergès S, Treand C, "et al." |title=Luman, a new partner of HIV-1 TMgp41, interferes with Tat-mediated transcription of the HIV-1 LTR. |journal=J. Mol. Biol. |volume=364 |issue= 5 |pages= 1034–47 |year= 2007 |pmid= 17054986 |doi= 10.1016/j.jmb.2006.09.080
*cite journal | author=Jang SW, Kim YS, Lee YH, Ko J |title=Role of human LZIP in differential activation of the NF-kappaB pathway that is induced by CCR1-dependent chemokines. |journal=J. Cell. Physiol. |volume=211 |issue= 3 |pages= 630–7 |year= 2007 |pmid= 17192849 |doi= 10.1002/jcp.20968
*cite journal | author=Jang SW, Kim YS, Kim YR, "et al." |title=Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1. |journal=J. Biol. Chem. |volume=282 |issue= 15 |pages= 11092–100 |year= 2007 |pmid= 17296613 |doi= 10.1074/jbc.M607962200

External links


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