BMAL


BMAL

protein
Name=aryl hydrocarbon receptor nuclear translocator-like
caption=


width=
HGNCid=701
Symbol=ARNTL
AltSymbols=
EntrezGene=406
OMIM=602550
RefSeq=NM_001178
UniProt=O00327
PDB=
ECnumber=
Chromosome=11
Arm=p
Band=15
LocusSupplementaryData=
protein
Name=aryl hydrocarbon receptor nuclear translocator-like 2
caption=


width=
HGNCid=18984
Symbol=ARNTL2
AltSymbols=
EntrezGene=56938
OMIM=
RefSeq=NM_020183
UniProt=Q8WYA4
PDB=
ECnumber=
Chromosome=12
Arm=p
Band=12.2
LocusSupplementaryData=-11.2

Bmal (brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like) is a gene which encodes proteins regulating circadian rhythm. BMAL proteins form part of a basic-helix-loop-helix transcription factor. BMAL-1 dimerizes with CLOCK "in vivo" and transactivates gene expression of Period and Timeless in drosophila by binding to E-box elements in their promoters.cite journal | author = Ishida N, Kaneko M, Allada R | title = Biological clocks | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 16 | pages = 8819–20 | year = 1999 | pmid = 10430850 | doi = 10.1073/pnas.96.16.8819 | issn = ] BMAL1-CLOCK also regulates Cryptochrome genes (e.g. Cry1, Cry2) and Period genes (e.g. Per1, Per2, Per3).cite journal | author = Edery I | title = Circadian rhythms in a nutshell | journal = Physiol. Genomics | volume = 3 | issue = 2 | pages = 59–74 | year = 2000 | pmid = 11015601 | doi = | issn = | url = http://physiolgenomics.physiology.org/cgi/content/abstract/3/2/59 ]

ee also

* Suprachiasmatic nucleus
* CLOCK

References

External links

*


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