Zinc finger protein 423, also known as ZNF423, is a human gene.cite web | title = Entrez Gene: ZNF423 zinc finger protein 423| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23090| accessdate = ]

The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development.


Further reading

*cite journal | author=Warming S, Rachel RA, Jenkins NA, Copeland NG. |title=Zfp423 is required for normal cerebellar development. |journal=Mol Cell Biol. |volume=26 |issue= 18 |pages= 6913-22. |year= 2006 |pmid= 16943432
*cite journal | author=Alcaraz WA, Gold DA, Raponi E, "et al." |title=Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation. |journal=Proc Natl Acad Sci U S A. |volume=103 |issue= 51 |pages= 19424-9. |year= 2006 |pmid= 17151198
*cite journal | author=Cheng LE, Reed RR. |title=Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis. |journal=Neuron |volume=54 |issue= 4 |pages= 547-57. |year= 2007 |pmid= 17521568
*cite journal | author=Cheng LE, Zhang J, Reed RR |title=The transcription factor Zfp423/OAZ is required for cerebellar development and CNS midline patterning. |journal=Dev Biol. |volume=307 |issue= 1 |pages= 43–52 |year= 2007 |pmid= 17524391 |doi= 10.1016/j.ydbio.2007.04.005 PBB_Further_reading
citations =
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Ku MC, Stewart S, Hata A |title=Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes. |journal=Biochem. Biophys. Res. Commun. |volume=311 |issue= 3 |pages= 702–7 |year= 2004 |pmid= 14623329 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shim S, Bae N, Han JK |title=Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/EBF associated zinc finger (OAZ). |journal=Nucleic Acids Res. |volume=30 |issue= 14 |pages= 3107–17 |year= 2002 |pmid= 12136093 |doi=
*cite journal | author=Hata A, Seoane J, Lagna G, "et al." |title=OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. |journal=Cell |volume=100 |issue= 2 |pages= 229–40 |year= 2000 |pmid= 10660046 |doi=
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277–86 |year= 1999 |pmid= 9872452 |doi=
*cite journal | author=Tsai RY, Reed RR |title=Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development. |journal=J. Neurosci. |volume=17 |issue= 11 |pages= 4159–69 |year= 1997 |pmid= 9151733 |doi=
*cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, "et al." |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457

External links


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