- SOX genes
"SOX" genes encode a family of
transcription factors that bind to the minor groovein DNA, and belong to a super-family of genescharacterized by a homologous sequence called the HMG ( high mobility group) box. This HMG box is a DNA binding domainthat is highly conserved throughout eukaryotic species. Homologues have been identified in insects, nematodes, amphibians, reptiles, birds and a range of mammals. However, HMG boxes can be very diverse in nature, with only a few amino acidsbeing conserved between species.
Sox genes are defined as containing the HMG box of a gene involved in sex determination called "
SRY", which resides on the Y-chromosome(Sox stands for Sry-related HMG box). Around 30 SOX genes have been identified. There are 20 present in humans and mice, and 8 present in Drosophila. Almost all Sox genes show at least 50% amino acid similarity with the HMG box in Sry. The family is divided into subgroups according to homology within the HMG domain and other structural motifs, as well as according to functional assays.
The developmentally important Sox family has no singular function, and many members possess the ability to regulate several different aspects of development. While many Sox genes are involved in sex determination, some are also important in processes such as
neuronaldevelopment. For example, Sox2 and Sox3 are involved in the transition between epithelial granule cells in the cerebellum to their migratory state. Granule cells then differentiate to granule neurons, with Sox11 being involved in this process. It is thought that some Sox genes may be useful in the early diagnosis of childhood brain tumours due to this sequential expression in the cerebellum, making them a target for significant research.
Sox4 is a transcription factor in lymphocytes (B and T) and is required for B lymphocyte development.cite journal |author=Smith E, Sigvardsson M |title=The roles of transcription factors in B lymphocyte commitment, development, and transformation |journal=J. Leukoc. Biol. |volume=75 |issue=6 |pages=973–81 |year=2004 |pmid=14982952 |doi=10.1189/jlb.1103554]
SOX1(Gene|SOX1), SOX2(Gene|SOX2), SOX3(Gene|SOX3), SOX4(Gene|SOX4), SOX5(Gene|SOX5), SOX6(Gene|SOX6), SOX7(Gene|SOX7), SOX8(Gene|SOX8), SOX9(Gene|SOX9), SOX10(Gene|SOX10), SOX11(Gene|SOX11), SOX12(Gene|SOX12), SOX13(Gene|SOX13), SOX14(Gene|SOX14), SOX15(Gene|SOX15), SOX17(Gene|SOX17), SOX18(Gene|SOX18), SOX21(Gene|SOX21), SOX30(Gene|SOX30)
Evolutionary developmental biology
title=Granule cell development in the cerebellum is punctuated by changes in Sox gene expression
journal=Brain research. Molecular Brain Research.
title=From head to toes: the multiple facets of Sox proteins
journal= Nucleic Acids Res.
coauthors= Snopek B; Koopman P.
title=Seven new members of the Sox gene family expressed during mouse development.
journal= Nucleic Acids Res.
coauthors= Schepers G; Koopman P.
title=Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.
journal= Dev Biol.
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Look at other dictionaries:
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SOX3 — SRY (sex determining region Y) box 3, also known as SOX3, is a human gene.cite web | title = Entrez Gene: SOX3 SRY (sex determining region Y) box 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=6658|… … Wikipedia
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