Interferon, gamma-inducible protein 16, also known as IFI16, is a human gene.cite web | title = Entrez Gene: IFI16 interferon, gamma-inducible protein 16| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3428| accessdate = ]

section_title =
summary_text = This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway.cite web | title = Entrez Gene: IFI16 interferon, gamma-inducible protein 16| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3428| accessdate = ]


Further reading

citations =
*cite journal | author=Trapani JA, Browne KA, Dawson MJ, "et al." |title=A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells. |journal=Immunogenetics |volume=36 |issue= 6 |pages= 369–76 |year= 1992 |pmid= 1526658 |doi=
*cite journal | author=Dawson MJ, Trapani JA |title=IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. |journal=J. Cell. Biochem. |volume=57 |issue= 1 |pages= 39–51 |year= 1995 |pmid= 7536752 |doi= 10.1002/jcb.240570106
*cite journal | author=Dawson MJ, Trapani JA, Briggs RC, "et al." |title=The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression. |journal=Immunogenetics |volume=41 |issue= 1 |pages= 40–3 |year= 1995 |pmid= 7806273 |doi=
*cite journal | author=Trapani JA, Dawson M, Apostolidis VA, Browne KA |title=Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization. |journal=Immunogenetics |volume=40 |issue= 6 |pages= 415–24 |year= 1994 |pmid= 7959953 |doi=
*cite journal | author=Johnstone RW, Kerry JA, Trapani JA |title=The human interferon-inducible protein, IFI 16, is a repressor of transcription. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 17172–7 |year= 1998 |pmid= 9642285 |doi=
*cite journal | author=Johnstone RW, Kershaw MH, Trapani JA |title=Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing. |journal=Biochemistry |volume=37 |issue= 34 |pages= 11924–31 |year= 1998 |pmid= 9718316 |doi= 10.1021/bi981069a
*cite journal | author=Dawson MJ, Elwood NJ, Johnstone RW, Trapani JA |title=The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations. |journal=J. Leukoc. Biol. |volume=64 |issue= 4 |pages= 546–54 |year= 1998 |pmid= 9766636 |doi=
*cite journal | author=Briggs LJ, Johnstone RW, Elliot RM, "et al." |title=Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16. |journal=Biochem. J. |volume=353 |issue= Pt 1 |pages= 69–77 |year= 2001 |pmid= 11115400 |doi=
*cite journal | author=Johnstone RW, Wei W, Greenway A, Trapani JA |title=Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16. |journal=Oncogene |volume=19 |issue= 52 |pages= 6033–42 |year= 2001 |pmid= 11146555 |doi= 10.1038/sj.onc.1204005
*cite journal | author=Gariglio M, Azzimonti B, Pagano M, "et al." |title=Immunohistochemical expression analysis of the human interferon-inducible gene IFI16, a member of the HIN200 family, not restricted to hematopoietic cells. |journal=J. Interferon Cytokine Res. |volume=22 |issue= 7 |pages= 815–21 |year= 2003 |pmid= 12184920 |doi= 10.1089/107999002320271413
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Izmailova E, Bertley FM, Huang Q, "et al." |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822
*cite journal | author=Clarke CJ, Apostolidis V, Hii LL, "et al." |title=Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16. |journal=J. Cell. Biochem. |volume=89 |issue= 1 |pages= 80–93 |year= 2003 |pmid= 12682910 |doi= 10.1002/jcb.10475
*cite journal | author=Xin H, Curry J, Johnstone RW, "et al." |title=Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. |journal=Oncogene |volume=22 |issue= 31 |pages= 4831–40 |year= 2003 |pmid= 12894224 |doi= 10.1038/sj.onc.1206754
*cite journal | author=Kwak JC, Ongusaha PP, Ouchi T, Lee SW |title=IFI16 as a negative regulator in the regulation of p53 and p21(Waf1). |journal=J. Biol. Chem. |volume=278 |issue= 42 |pages= 40899–904 |year= 2003 |pmid= 12925527 |doi= 10.1074/jbc.M308012200
*cite journal | author=Aglipay JA, Lee SW, Okada S, "et al." |title=A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. |journal=Oncogene |volume=22 |issue= 55 |pages= 8931–8 |year= 2004 |pmid= 14654789 |doi= 10.1038/sj.onc.1207057
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Raffaella R, Gioia D, De Andrea M, "et al." |title=The interferon-inducible IFI16 gene inhibits tube morphogenesis and proliferation of primary, but not HPV16 E6/E7-immortalized human endothelial cells. |journal=Exp. Cell Res. |volume=293 |issue= 2 |pages= 331–45 |year= 2004 |pmid= 14729471 |doi=
*cite journal | author=Fujiuchi N, Aglipay JA, Ohtsuka T, "et al." |title=Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. |journal=J. Biol. Chem. |volume=279 |issue= 19 |pages= 20339–44 |year= 2004 |pmid= 14990579 |doi= 10.1074/jbc.M400344200
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101

External links


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