High mobility group AT-hook 2, also known as HMGA2, is a human gene.cite web | title = Entrez Gene: HMGA2 high mobility group AT-hook 2| url =| accessdate = ]

section_title =
summary_text = This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.cite web | title = Entrez Gene: HMGA2 high mobility group AT-hook 2| url =| accessdate = ]

ee also



Further reading

citations =
*cite journal | author=Pedeutour F, Ligon AH, Morton CC |title= [Genetics of uterine leiomyomata] |journal=Bulletin du cancer |volume=86 |issue= 11 |pages= 920–8 |year= 1999 |pmid= 10586108 |doi=
*cite journal | author=Reeves R, Beckerbauer L |title=HMGI/Y proteins: flexible regulators of transcription and chromatin structure. |journal=Biochim. Biophys. Acta |volume=1519 |issue= 1-2 |pages= 13–29 |year= 2001 |pmid= 11406267 |doi=
*cite journal | author=Manfioletti G, Giancotti V, Bandiera A, "et al." |title=cDNA cloning of the HMGI-C phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypes. |journal=Nucleic Acids Res. |volume=19 |issue= 24 |pages= 6793–7 |year= 1992 |pmid= 1762909 |doi=
*cite journal | author=Chau KY, Patel UA, Lee KL, "et al." |title=The gene for the human architectural transcription factor HMGI-C consists of five exons each coding for a distinct functional element. |journal=Nucleic Acids Res. |volume=23 |issue= 21 |pages= 4262–6 |year= 1996 |pmid= 7501444 |doi=
*cite journal | author=Schoenmakers EF, Mols R, Wanschura S, "et al." |title=Identification, molecular cloning, and characterization of the chromosome 12 breakpoint cluster region of uterine leiomyomas. |journal=Genes Chromosomes Cancer |volume=11 |issue= 2 |pages= 106–18 |year= 1995 |pmid= 7529547 |doi=
*cite journal | author=Ashar HR, Fejzo MS, Tkachenko A, "et al." |title=Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. |journal=Cell |volume=82 |issue= 1 |pages= 57–65 |year= 1995 |pmid= 7606786 |doi=
*cite journal | author=Schoenmakers EF, Wanschura S, Mols R, "et al." |title=Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. |journal=Nat. Genet. |volume=10 |issue= 4 |pages= 436–44 |year= 1995 |pmid= 7670494 |doi= 10.1038/ng0895-436
*cite journal | author=Patel UA, Bandiera A, Manfioletti G, "et al." |title=Expression and cDNA cloning of human HMGI-C phosphoprotein. |journal=Biochem. Biophys. Res. Commun. |volume=201 |issue= 1 |pages= 63–70 |year= 1994 |pmid= 8198613 |doi=
*cite journal | author=Ashar HR, Cherath L, Przybysz KM, Chada K |title=Genomic characterization of human HMGIC, a member of the accessory transcription factor family found at translocation breakpoints in lipomas. |journal=Genomics |volume=31 |issue= 2 |pages= 207–14 |year= 1997 |pmid= 8824803 |doi= 10.1006/geno.1996.0033
*cite journal | author=Ishwad CS, Shriver MD, Lassige DM, Ferrell RE |title=The high mobility group I-C gene (HMGI-C): polymorphism and genetic localization. |journal=Hum. Genet. |volume=99 |issue= 1 |pages= 103–5 |year= 1997 |pmid= 9003504 |doi=
*cite journal | author=Petit MM, Swarts S, Bridge JA, Van de Ven WJ |title=Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma. |journal=Cancer Genet. Cytogenet. |volume=106 |issue= 1 |pages= 18–23 |year= 1998 |pmid= 9772904 |doi=
*cite journal | author=Schoenmakers EF, Huysmans C, Van de Ven WJ |title=Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas. |journal=Cancer Res. |volume=59 |issue= 1 |pages= 19–23 |year= 1999 |pmid= 9892177 |doi=
*cite journal | author=Gattas GJ, Quade BJ, Nowak RA, Morton CC |title=HMGIC expression in human adult and fetal tissues and in uterine leiomyomata. |journal=Genes Chromosomes Cancer |volume=25 |issue= 4 |pages= 316–22 |year= 1999 |pmid= 10398424 |doi=
*cite journal | author=Schwanbeck R, Manfioletti G, Wiśniewski JR |title=Architecture of high mobility group protein I-C.DNA complex and its perturbation upon phosphorylation by Cdc2 kinase. |journal=J. Biol. Chem. |volume=275 |issue= 3 |pages= 1793–801 |year= 2000 |pmid= 10636877 |doi=
*cite journal | author=Piekielko A, Drung A, Rogalla P, "et al." |title=Distinct organization of DNA complexes of various HMGI/Y family proteins and their modulation upon mitotic phosphorylation. |journal=J. Biol. Chem. |volume=276 |issue= 3 |pages= 1984–92 |year= 2001 |pmid= 11034995 |doi= 10.1074/jbc.M004065200
*cite journal | author=Rogalla P, Lemke I, Kazmierczak B, Bullerdiek J |title=An identical HMGIC-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15). |journal=Genes Chromosomes Cancer |volume=29 |issue= 4 |pages= 363–6 |year= 2001 |pmid= 11066083 |doi=
*cite journal | author=Zentner MD, Lin HH, Deng HT, "et al." |title=Requirement for high mobility group protein HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit of epithelial Na+ channel (alpha-ENaC) transcription by Ras activation in salivary epithelial cells. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29805–14 |year= 2001 |pmid= 11390395 |doi= 10.1074/jbc.M103153200
*cite journal | author=Röijer E, Nordkvist A, Ström AK, "et al." |title=Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma. |journal=Am. J. Pathol. |volume=160 |issue= 2 |pages= 433–40 |year= 2002 |pmid= 11839563 |doi=

External links

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