Liver X receptor beta


Liver X receptor beta
Nuclear receptor subfamily 1, group H, member 2

PDB rendering based on 1p8d.
Identifiers
Symbols NR1H2; LXR-b; LXRB; NER; NER-I; RIP15; UNR
External IDs OMIM600380 MGI1352463 HomoloGene21397 IUPHAR: NR1H2 GeneCards: NR1H2 Gene
RNA expression pattern
PBB GE NR1H2 218215 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7376 22260
Ensembl ENSG00000131408 ENSMUSG00000060601
UniProt P55055 Q8BP65
RefSeq (mRNA) NM_007121 NM_009473.2
RefSeq (protein) NP_009052 NP_033499.1
Location (UCSC) Chr 19:
50.83 – 50.89 Mb
Chr 7:
51.8 – 51.81 Mb
PubMed search [1] [2]

Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2).[1]

Contents

Function

The liver X receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA) and beta, are known to encode LXR proteins.[2][1]

Interactions

Liver X receptor beta has been shown to interact with NCOA6[3] and Retinoid X receptor alpha.[4]

References

  1. ^ a b "Entrez Gene: NR1H2 nuclear receptor subfamily 1, group H, member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7376. 
  2. ^ Song C, Hiipakka RA, Kokontis JM, Liao S (June 1995). "Ubiquitous receptor: structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones". Ann. N. Y. Acad. Sci. 761: 38–49. doi:10.1111/j.1749-6632.1995.tb31367.x. PMID 7625741. 
  3. ^ Lee SK, Jung SY, Kim YS, Na SY, Lee YC, Lee JW (February 2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2". Mol. Endocrinol. 15 (2): 241–54. doi:10.1210/me.15.2.241. PMID 11158331. 
  4. ^ Seol W, Choi HS, Moore DD (January 1995). "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors". Mol. Endocrinol. 9 (1): 72–85. doi:10.1210/me.9.1.72. PMID 7760852. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Liver X receptor — protein Name=LXRα (nuclear receptor subfamily 1, group H, member 3) caption= width= HGNCid=7966 Symbol=NR1H3 AltSymbols= EntrezGene=10062 OMIM=602423 RefSeq=NM 005693 UniProt=Q13133 PDB= ECnumber= Chromosome= Arm= Band=… …   Wikipedia

  • Liver X receptor alpha — Nuclear receptor subfamily 1, group H, member 3 PDB rendering based on 1uhl …   Wikipedia

  • Retinoic acid receptor beta — Retinoic acid receptor, beta PDB rendering based on 1dsz …   Wikipedia

  • Retinoid X receptor beta — Retinoid X receptor, beta PDB rendering based on 1by4 …   Wikipedia

  • Beta blocker — Beta blockers Drug class Skeletal formula of propranolol, the first clinically successful beta blocker ATC code C07 …   Wikipedia

  • Liver receptor homolog-1 — Nuclear receptor subfamily 5, group A, member 2 PDB rendering based on 1yok …   Wikipedia

  • Beta-2 adrenergic receptor — The beta 2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is an beta adrenergic receptor, and also denotes the human gene encoding it.cite web | title = Entrez Gene: ADRB1 adrenergic, beta 1 , receptor| url =… …   Wikipedia

  • Beta-catenin — is a subunit of the cadherin protein complex. In Drosophila , the homologous protein is called armadillo . Beta catenin has been implicated as an integral component in the Wnt signaling pathway.It can function as an oncogene.cite journal… …   Wikipedia

  • Beta-glucan — Diagram showing orientation and location of different beta glucan linkages …   Wikipedia

  • Beta barrel — A beta barrel is a large beta sheet that twists and coils to form a closed structure in which the first strand is hydrogen bonded to the last. Beta strands in beta barrels are typically arranged in an antiparallel fashion. Barrel structures are… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.