NK2 homeobox 2
Symbols NKX2-2; NKX2.2; NKX2B
External IDs OMIM604612 MGI97347 HomoloGene1879 GeneCards: NKX2-2 Gene
RNA expression pattern
PBB GE NKX2-2 206915 at tn.png
More reference expression data
Species Human Mouse
Entrez 4821 18088
Ensembl ENSG00000125820 ENSMUSG00000027434
UniProt O95096 Q3URZ4
RefSeq (mRNA) NM_002509 XM_001004391
RefSeq (protein) NP_002500 XP_001004391
Location (UCSC) Chr 20:
21.49 – 21.49 Mb
Chr 2:
147 – 147.02 Mb
PubMed search [1] [2]

Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene.[1][2][3]

Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.[3]

The expression of Nkx2-2 is regulated by an antisense RNA called Nkx2-2as.[4]


  1. ^ Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI (Sep 1998). "Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese". Diabetes 47 (8): 1356–8. doi:10.2337/diabetes.47.8.1356. PMID 9703340. 
  2. ^ Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R (Mar 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron 8 (2): 241–55. doi:10.1016/0896-6273(92)90291-K. PMID 1346742. 
  3. ^ a b "Entrez Gene: NKX2-2 NK2 transcription factor related, locus 2 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4821. 
  4. ^ Tochitani S, Hayashizaki Y (August 2008). "Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation". Biochem. Biophys. Res. Commun. 372 (4): 691–6. doi:10.1016/j.bbrc.2008.05.127. PMID 18538132. 

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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