ID4 (gene)

ID4 (gene)

Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein, also known as ID4, is a human gene.cite web | title = Entrez Gene: ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein| url =| accessdate = ]

section_title =
summary_text = Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995). [supplied by OMIM] cite web | title = Entrez Gene: ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein| url =| accessdate = ]

See also

* Inhibitor of DNA-binding protein


Further reading

citations =
*cite journal | author=Pagliuca A, Bartoli PC, Saccone S, "et al." |title=Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22. |journal=Genomics |volume=27 |issue= 1 |pages= 200–3 |year= 1995 |pmid= 7665172 |doi= 10.1006/geno.1995.1026
*cite journal | author=Loveys DA, Streiff MB, Kato GJ |title=E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein. |journal=Nucleic Acids Res. |volume=24 |issue= 14 |pages= 2813–20 |year= 1996 |pmid= 8759016 |doi=
*cite journal | author=Stewart HJ, Zoidl G, Rossner M, "et al." |title=Helix-loop-helix proteins in Schwann cells: a study of regulation and subcellular localization of Ids, REB, and E12/47 during embryonic and postnatal development. |journal=J. Neurosci. Res. |volume=50 |issue= 5 |pages= 684–701 |year= 1998 |pmid= 9418957 |doi=
*cite journal | author=Rigolet M, Rich T, Gross-Morand MS, "et al." |title=cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene. |journal=DNA Res. |volume=5 |issue= 5 |pages= 309–13 |year= 1999 |pmid= 9872455 |doi=
*cite journal | author=Beger C, Pierce LN, Kruger M, "et al." |title=Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 1 |pages= 130–5 |year= 2001 |pmid= 11136250 |doi= 10.1073/pnas.98.1.130
*cite journal | author=Jögi A, Persson P, Grynfeld A, "et al." |title=Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9118–26 |year= 2002 |pmid= 11756408 |doi= 10.1074/jbc.M107713200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bellido M, Aventín A, Lasa A, "et al." |title=Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia. |journal=Haematologica |volume=88 |issue= 9 |pages= 994–1001 |year= 2004 |pmid= 12969807 |doi=
*cite journal | author=Chan AS, Tsui WY, Chen X, "et al." |title=Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma. |journal=Oncogene |volume=22 |issue= 44 |pages= 6946–53 |year= 2003 |pmid= 14534543 |doi= 10.1038/sj.onc.1206799
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Shan L, Yu M, Qiu C, Snyderwine EG |title=Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas. |journal=Am. J. Pathol. |volume=163 |issue= 6 |pages= 2495–502 |year= 2004 |pmid= 14633621 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Umetani N, Takeuchi H, Fujimoto A, "et al." |title=Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis. |journal=Clin. Cancer Res. |volume=10 |issue= 22 |pages= 7475–83 |year= 2005 |pmid= 15569977 |doi= 10.1158/1078-0432.CCR-04-0689
*cite journal | author=Yu L, Liu C, Vandeusen J, "et al." |title=Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. |journal=Nat. Genet. |volume=37 |issue= 3 |pages= 265–74 |year= 2005 |pmid= 15723065 |doi= 10.1038/ng1521
*cite journal | author=Wu Q, Hoffmann MJ, Hartmann FH, Schulz WA |title=Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer. |journal=Mol. Cancer |volume=4 |issue= 1 |pages= 16 |year= 2006 |pmid= 15876350 |doi= 10.1186/1476-4598-4-16
*cite journal | author=Peddada S, Yasui DH, LaSalle JM |title=Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome. |journal=Hum. Mol. Genet. |volume=15 |issue= 12 |pages= 2003–14 |year= 2006 |pmid= 16682435 |doi= 10.1093/hmg/ddl124
*cite journal | author=Hagiwara K, Nagai H, Li Y, "et al." |title=Frequent DNA methylation but not mutation of the ID4 gene in malignant lymphoma. |journal=Journal of clinical and experimental hematopathology : JCEH |volume=47 |issue= 1 |pages= 15–8 |year= 2007 |pmid= 17510533 |doi=
*cite journal | author=Noetzel E, Veeck J, Niederacher D, "et al." |title=Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer. |journal=BMC Cancer. |volume=R8 |issue= 154 |year= 2008 |pmid= 18513385 |doi=10.1186/1471-2407-8-154 |pages=154

External links


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