FOXE1


FOXE1

Forkhead box E1 (thyroid transcription factor 2), also known as FOXE1, is a human gene.cite web | title = Entrez Gene: FOXE1 forkhead box E1 (thyroid transcription factor 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2304| accessdate = ]

PBB_Summary
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summary_text = This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I.cite web | title = Entrez Gene: FOXE1 forkhead box E1 (thyroid transcription factor 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2304| accessdate = ]

ee also

* FOX proteins

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wiese S, Emmerich D, Schröder B, "et al." |title=The novel human HNF-3/fork head-like 5 gene: chromosomal localization and expression pattern. |journal=DNA Cell Biol. |volume=16 |issue= 2 |pages= 165–71 |year= 1997 |pmid= 9052737 |doi=
*cite journal | author=Chadwick BP, Obermayr F, Frischauf AM |title=FKHL15, a new human member of the forkhead gene family located on chromosome 9q22. |journal=Genomics |volume=41 |issue= 3 |pages= 390–6 |year= 1997 |pmid= 9169137 |doi= 10.1006/geno.1997.4692
*cite journal | author=Zannini M, Avantaggiato V, Biffali E, "et al." |title=TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. |journal=EMBO J. |volume=16 |issue= 11 |pages= 3185–97 |year= 1997 |pmid= 9214635 |doi= 10.1093/emboj/16.11.3185
*cite journal | author=Clifton-Bligh RJ, Wentworth JM, Heinz P, "et al." |title=Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia. |journal=Nat. Genet. |volume=19 |issue= 4 |pages= 399–401 |year= 1998 |pmid= 9697705 |doi= 10.1038/1294
*cite journal | author=Macchia PE, Mattei MG, Lapi P, "et al." |title=Cloning, chromosomal localization and identification of polymorphisms in the human thyroid transcription factor 2 gene (TITF2). |journal=Biochimie |volume=81 |issue= 5 |pages= 433–40 |year= 1999 |pmid= 10403172 |doi=
*cite journal | author=Wang JC, Waltner-Law M, Yamada K, "et al." |title=Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18418–23 |year= 2000 |pmid= 10748198 |doi= 10.1074/jbc.M910211199
*cite journal | author=Sequeira MJ, Morgan JM, Fuhrer D, "et al." |title=Thyroid transcription factor-2 gene expression in benign and malignant thyroid lesions. |journal=Thyroid |volume=11 |issue= 11 |pages= 995–1001 |year= 2002 |pmid= 11762722 |doi= 10.1089/105072501753271662
*cite journal | author=Castanet M, Park SM, Smith A, "et al." |title=A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate. |journal=Hum. Mol. Genet. |volume=11 |issue= 17 |pages= 2051–9 |year= 2003 |pmid= 12165566 |doi=
*cite journal | author=Sequeira M, Al-Khafaji F, Park S, "et al." |title=Production and application of polyclonal antibody to human thyroid transcription factor 2 reveals thyroid transcription factor 2 protein expression in adult thyroid and hair follicles and prepubertal testis. |journal=Thyroid |volume=13 |issue= 10 |pages= 927–32 |year= 2004 |pmid= 14611701 |doi= 10.1089/105072503322511328
*cite journal | author=Romanelli MG, Tato' L, Lorenzi P, Morandi C |title=Nuclear localization domains in human thyroid transcription factor 2. |journal=Biochim. Biophys. Acta |volume=1643 |issue= 1-3 |pages= 55–64 |year= 2004 |pmid= 14654228 |doi=
*cite journal | author=Eichberger T, Regl G, Ikram MS, "et al." |title=FOXE1, a new transcriptional target of GLI2 is expressed in human epidermis and basal cell carcinoma. |journal=J. Invest. Dermatol. |volume=122 |issue= 5 |pages= 1180–7 |year= 2004 |pmid= 15140221 |doi= 10.1111/j.0022-202X.2004.22505.x
*cite journal | author=Tonacchera M, Banco M, Lapi P, "et al." |title=Genetic analysis of TTF-2 gene in children with congenital hypothyroidism and cleft palate, congenital hypothyroidism, or isolated cleft palate. |journal=Thyroid |volume=14 |issue= 8 |pages= 584–8 |year= 2005 |pmid= 15320969 |doi= 10.1089/1050725041692864
*cite journal | author=Brancaccio A, Minichiello A, Grachtchouk M, "et al." |title=Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in hair follicle morphogenesis. |journal=Hum. Mol. Genet. |volume=13 |issue= 21 |pages= 2595–606 |year= 2005 |pmid= 15367491 |doi= 10.1093/hmg/ddh292
*cite journal | author=Watkins WJ, Harris SE, Craven MJ, "et al." |title=An investigation into FOXE1 polyalanine tract length in premature ovarian failure. |journal=Mol. Hum. Reprod. |volume=12 |issue= 3 |pages= 145–9 |year= 2006 |pmid= 16481406 |doi= 10.1093/molehr/gal017
*cite journal | author=Baris I, Arisoy AE, Smith A, "et al." |title=A novel missense mutation in human TTF-2 (FKHL15) gene associated with congenital hypothyroidism but not athyreosis. |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue= 10 |pages= 4183–7 |year= 2006 |pmid= 16882747 |doi= 10.1210/jc.2006-0405

External links

*

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