ARNTL2


ARNTL2

Aryl hydrocarbon receptor nuclear translocator-like 2, also known as Mop9,cite journal |author=Hogenesch JB, Gu YZ, Moran SM, "et al" |title=The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors |journal=J. Neurosci. |volume=20 |issue=13 |pages=RC83 |year=2000 |pmid=10864977 |doi=] Bmal2,cite journal |author=Ikeda M, Yu W, Hirai M, "et al" |title=cDNA cloning of a novel bHLH-PAS transcription factor superfamily gene, BMAL2: its mRNA expression, subcellular distribution, and chromosomal localization |journal=Biochem. Biophys. Res. Commun. |volume=275 |issue=2 |pages=493–502 |year=2000 |pmid=10964693 |doi=10.1006/bbrc.2000.3248] CLIF,cite journal |author=Maemura K, de la Monte SM, Chin MT, "et al" |title=CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression |journal=J. Biol. Chem. |volume=275 |issue=47 |pages=36847–51 |year=2000 |pmid=11018023 |doi=10.1074/jbc.C000629200] , or ARNTL2"', is a gene.

Arntl2 is a mammalian paralog (with ARNTL) of the Drosophila Cycle gene, and interacts with both Clock and NPAS2 to bind to E-box sequences in regulated promoters and activate their transcription.cite journal |author=Hogenesch JB, Gu YZ, Moran SM, "et al" |title=The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors |journal=J. Neurosci. |volume=20 |issue=13 |pages=RC83 |year=2000 |pmid=10864977 |doi=] Although Arntl2 is not required for normal function of the mammalian circadian oscillator, it may play an important role in mediating the output of the circadian clock. Perhaps because of this, there is relatively little published literature on the role of Arntl2 in regulation of physiology.

Arntl2 is a candidate gene for human type 1 diabetes.cite journal |author=Hung MS, Avner P, Rogner UC |title=Identification of the transcription factor ARNTL2 as a candidate gene for the type 1 diabetes locus Idd6 |journal=Hum. Mol. Genet. |volume=15 |issue=18 |pages=2732–42 |year=2006 |pmid=16893914 |doi=10.1093/hmg/ddl209]

In over expression studies, Arntl2 forms a heterodimer with Clock to regulate E-box sequences in the Pai-1 promoter.cite journal |author=Maemura K, de la Monte SM, Chin MT, "et al" |title=CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression |journal=J. Biol. Chem. |volume=275 |issue=47 |pages=36847–51 |year=2000 |pmid=11018023 |doi=10.1074/jbc.C000629200] Recent work suggest that this interaction may be in concert with Arntl/Clock heterodimeric complexes.cite journal |author=Schoenhard JA, Smith LH, Painter CA, Eren M, Johnson CH, Vaughan DE |title=Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2 |journal=J. Mol. Cell. Cardiol. |volume=35 |issue=5 |pages=473–81 |year=2003 |pmid=12738229 |doi=]

ee also

* BMAL

References

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • ARNTL2 — Receptor nuclear translocador tipo 2 de aril hidrocarburos HUGO 18984 Símbolo ARNTL2 Símbolos alt. BMAL2, CLIF, MGC149671 …   Wikipedia Español

  • Circadian rhythm — Circadian redirects here. For the album by the rock band 5th Projekt, see Circadian (album). Some features of the human circadian biological clock A circadian rhythm, popularly referred to as body clock, is an endogenously driven, roughly 24 hour …   Wikipedia

  • Receptor (biochemistry) — For other uses, see Receptor (disambiguation). In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism. These signals… …   Wikipedia

  • CREB — redirects here. For other uses, see Clean Renewable Energy Bonds. CREB (top) is a transcription factor capable of binding DNA (bottom) and regulating gene expression. CREB (cAMP response element binding) is a cellular transcription factor. It… …   Wikipedia

  • MyoD — Myogenic differentiation 1 PDB rendering based on 1mdy …   Wikipedia

  • Oct-4 — POU class 5 homeobox 1 Identifiers Symbols POU5F1; MGC22487; OCT3; OCT4; OTF 3; OTF3; OTF4; Oct 3; Oct 4 External IDs …   Wikipedia

  • Estrogen receptor — 1 (ER alpha) A dimer of the ligand binding region of ERα (PDB rendering based on 3erd). Identifi …   Wikipedia

  • Progesterone receptor — PDB rendering based on 1a28 …   Wikipedia

  • Androgen receptor — Structure of the ligand binding domain of the androgen receptor (rainbow cartoon) complexed with testosterone (white sticks).[1] …   Wikipedia

  • NF-κB — Mechanism of NF κB action. In this figure, the NF κB heterodimer between Rel and p50 proteins is used as an example. While in an inactivated state, NF κB is located in the cytosol complexed with the inhibitory protein IκBα. Through the… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.