Kruppel-like factor 6, also known as KLF6, is a human gene.

It is a tumor suppressor gene.cite journal |author=Li D, Yea S, Dolios G, "et al" |title=Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation |journal=Cancer Res. |volume=65 |issue=20 |pages=9216–25 |year=2005 |month=October |pmid=16230382 |doi=10.1158/0008-5472.CAN-05-1040 |url=http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16230382]

section_title =
summary_text = This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.cite web | title = Entrez Gene: KLF6 Kruppel-like factor 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1316| accessdate = ]

ee also

* Kruppel-like factors


Further reading

citations =
*cite journal | author=Narla G, Friedman SL, Martignetti JA |title=Krüppel cripples prostate cancer: KLF6 progress and prospects. |journal=Am. J. Pathol. |volume=162 |issue= 4 |pages= 1047–52 |year= 2003 |pmid= 12651597 |doi=
*cite journal | author=El Rouby S, Newcomb EW |title=Identification of Bcd, a novel proto-oncogene expressed in B-cells. |journal=Oncogene |volume=13 |issue= 12 |pages= 2623–30 |year= 1997 |pmid= 9000136 |doi=
*cite journal | author=Koritschoner NP, Bocco JL, Panzetta-Dutari GM, "et al." |title=A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene. |journal=J. Biol. Chem. |volume=272 |issue= 14 |pages= 9573–80 |year= 1997 |pmid= 9083102 |doi=
*cite journal | author=Onyango P, Koritschoner NP, Patrito LC, "et al." |title=Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization. |journal=Genomics |volume=48 |issue= 1 |pages= 143–4 |year= 1998 |pmid= 9503030 |doi= 10.1006/geno.1997.5124
*cite journal | author=Suzuki T, Yamamoto T, Kurabayashi M, "et al." |title=Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter. |journal=J. Biochem. |volume=124 |issue= 2 |pages= 389–95 |year= 1998 |pmid= 9685731 |doi=
*cite journal | author=Ratziu V, Lalazar A, Wong L, "et al." |title=Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 16 |pages= 9500–5 |year= 1998 |pmid= 9689109 |doi=
*cite journal | author=Okano J, Opitz OG, Nakagawa H, "et al." |title=The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact. |journal=FEBS Lett. |volume=473 |issue= 1 |pages= 95–100 |year= 2000 |pmid= 10802067 |doi=
*cite journal | author=Narla G, Heath KE, Reeves HL, "et al." |title=KLF6, a candidate tumor suppressor gene mutated in prostate cancer. |journal=Science |volume=294 |issue= 5551 |pages= 2563–6 |year= 2002 |pmid= 11752579 |doi= 10.1126/science.1066326
*cite journal | author=Botella LM, Sánchez-Elsner T, Sanz-Rodriguez F, "et al." |title=Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury. |journal=Blood |volume=100 |issue= 12 |pages= 4001–10 |year= 2003 |pmid= 12433697 |doi= 10.1182/blood.V100.12.4001
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chen HK, Liu XQ, Lin J, "et al." |title= [Mutation analysis of KLF6 gene in human nasopharyngeal carcinomas] |journal=Ai Zheng |volume=21 |issue= 10 |pages= 1047–50 |year= 2003 |pmid= 12508640 |doi=
*cite journal | author=Warke VG, Nambiar MP, Krishnan S, "et al." |title=Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 14812–9 |year= 2003 |pmid= 12590140 |doi= 10.1074/jbc.M300787200
*cite journal | author=Chen C, Hyytinen ER, Sun X, "et al." |title=Deletion, mutation, and loss of expression of KLF6 in human prostate cancer. |journal=Am. J. Pathol. |volume=162 |issue= 4 |pages= 1349–54 |year= 2003 |pmid= 12651626 |doi=
*cite journal | author=Jeng YM, Hsu HC |title=KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas. |journal=Int. J. Cancer |volume=105 |issue= 5 |pages= 625–9 |year= 2003 |pmid= 12740910 |doi= 10.1002/ijc.11123
*cite journal | author=Bayat A, Watson JS, Stanley JK, "et al." |title=Genetic susceptibility to dupuytren disease: association of Zf9 transcription factor gene. |journal=Plast. Reconstr. Surg. |volume=111 |issue= 7 |pages= 2133–9 |year= 2003 |pmid= 12794452 |doi= 10.1097/01.PRS.0000060531.98180.32
*cite journal | author=Reeves HL, Narla G, Ogunbiyi O, "et al." |title=Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer. |journal=Gastroenterology |volume=126 |issue= 4 |pages= 1090–103 |year= 2004 |pmid= 15057748 |doi=
*cite journal | author=Kimmelman AC, Qiao RF, Narla G, "et al." |title=Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6. |journal=Oncogene |volume=23 |issue= 29 |pages= 5077–83 |year= 2004 |pmid= 15064720 |doi= 10.1038/sj.onc.1207662
*cite journal | author=Glinsky GV, Glinskii AB, Stephenson AJ, "et al." |title=Gene expression profiling predicts clinical outcome of prostate cancer. |journal=J. Clin. Invest. |volume=113 |issue= 6 |pages= 913–23 |year= 2004 |pmid= 15067324 |doi= 10.1172/JCI200420032
*cite journal | author=Rubinstein M, Idelman G, Plymate SR, "et al." |title=Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53. |journal=Endocrinology |volume=145 |issue= 8 |pages= 3769–77 |year= 2004 |pmid= 15131018 |doi= 10.1210/en.2004-0173

External links


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