Caudal type homeobox transcription factor 1, also known as CDX1, is a human gene.cite web | title = Entrez Gene: CDX1 caudal type homeobox transcription factor 1| url =| accessdate = ]

section_title =
summary_text = This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity.cite web | title = Entrez Gene: CDX1 caudal type homeobox transcription factor 1| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Bonner CA, Loftus SK, Wasmuth JJ |title=Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene. |journal=Genomics |volume=28 |issue= 2 |pages= 206–11 |year= 1996 |pmid= 8530027 |doi= 10.1006/geno.1995.1132
*cite journal | author= |title=Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome. The Treacher Collins Syndrome Collaborative Group. |journal=Nat. Genet. |volume=12 |issue= 2 |pages= 130–6 |year= 1996 |pmid= 8563749 |doi= 10.1038/ng0296-130
*cite journal | author=Mallo GV, Rechreche H, Frigerio JM, "et al." |title=Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. |journal=Int. J. Cancer |volume=74 |issue= 1 |pages= 35–44 |year= 1997 |pmid= 9036867 |doi=
*cite journal | author=Mizoshita T, Inada K, Tsukamoto T, "et al." |title=Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach. |journal=Gastric Cancer |volume=4 |issue= 4 |pages= 185–91 |year= 2002 |pmid= 11846061 |doi=
*cite journal | author=Suh ER, Ha CS, Rankin EB, "et al." |title=DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 35795–800 |year= 2002 |pmid= 12124393 |doi= 10.1074/jbc.M205567200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Domon-Dell C, Schneider A, Moucadel V, "et al." |title=Cdx1 homeobox gene during human colon cancer progression. |journal=Oncogene |volume=22 |issue= 39 |pages= 7913–21 |year= 2003 |pmid= 12970739 |doi= 10.1038/sj.onc.1206756
*cite journal | author=Wong NA, Britton MP, Choi GS, "et al." |title=Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 2 |pages= 574–9 |year= 2004 |pmid= 14704280 |doi= 10.1073/pnas.0307190101
*cite journal | author=Rankin EB, Xu W, Silberg DG, Suh E |title=Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=286 |issue= 5 |pages= G872–80 |year= 2004 |pmid= 14715525 |doi= 10.1152/ajpgi.00326.2003
*cite journal | author=Béland M, Pilon N, Houle M, "et al." |title=Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex. |journal=Mol. Cell. Biol. |volume=24 |issue= 11 |pages= 5028–38 |year= 2004 |pmid= 15143193 |doi= 10.1128/MCB.24.11.5028-5038.2004
*cite journal | author=Guo RJ, Huang E, Ezaki T, "et al." |title=Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity. |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36865–75 |year= 2004 |pmid= 15215241 |doi= 10.1074/jbc.M405213200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Alkhoury F, Malo MS, Mozumder M, "et al." |title=Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=289 |issue= 2 |pages= G285–90 |year= 2005 |pmid= 15774940 |doi= 10.1152/ajpgi.00037.2005
*cite journal | author=Wong NA, Wilding J, Bartlett S, "et al." |title=CDX1 is an important molecular mediator of Barrett's metaplasia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 21 |pages= 7565–70 |year= 2005 |pmid= 15894614 |doi= 10.1073/pnas.0502031102

External links


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