CAMP responsive element binding protein 1, also known as CREB1, is a human protein and gene. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.

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summary_text = This gene encodes a CREB transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [cite web | title = Entrez Gene: CREB1 cAMP responsive element binding protein 1| url =| accessdate = ]

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Further reading

citations =
*cite journal | author=Don J, Stelzer G |title=The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis. |journal=Mol. Cell. Endocrinol. |volume=187 |issue= 1-2 |pages= 115–24 |year= 2003 |pmid= 11988318 |doi=
*cite journal | author=Pandey SC |title=The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction. |journal=Pharmacol. Ther. |volume=104 |issue= 1 |pages= 47–58 |year= 2005 |pmid= 15500908 |doi= 10.1016/j.pharmthera.2004.08.002
*cite journal | author=Wu H, Zhou Y, Xiong ZQ |title=Transducer of regulated CREB and late phase long-term synaptic potentiation. |journal=FEBS J. |volume=274 |issue= 13 |pages= 3218–23 |year= 2007 |pmid= 17565597 |doi= 10.1111/j.1742-4658.2007.05891.x
*cite journal | author=Kitagawa K |title=CREB and cAMP response element-mediated gene expression in the ischemic brain. |journal=FEBS J. |volume=274 |issue= 13 |pages= 3210–7 |year= 2007 |pmid= 17565598 |doi= 10.1111/j.1742-4658.2007.05890.x
*cite journal | author=Takemori H, Kajimura J, Okamoto M |title=TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain. |journal=FEBS J. |volume=274 |issue= 13 |pages= 3202–9 |year= 2007 |pmid= 17565599 |doi= 10.1111/j.1742-4658.2007.05889.x
*cite journal | author=Siu YT, Jin DY |title=CREB--a real culprit in oncogenesis. |journal=FEBS J. |volume=274 |issue= 13 |pages= 3224–32 |year= 2007 |pmid= 17565603 |doi= 10.1111/j.1742-4658.2007.05884.x

External links


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