CREB1


CREB1

CAMP responsive element binding protein 1, also known as CREB1, is a human protein and gene. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.

PBB_Summary
section_title =
summary_text = This gene encodes a CREB transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [cite web | title = Entrez Gene: CREB1 cAMP responsive element binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1385| accessdate = ]

ee also

*CREB

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Don J, Stelzer G |title=The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis. |journal=Mol. Cell. Endocrinol. |volume=187 |issue= 1-2 |pages= 115–24 |year= 2003 |pmid= 11988318 |doi=
*cite journal | author=Pandey SC |title=The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction. |journal=Pharmacol. Ther. |volume=104 |issue= 1 |pages= 47–58 |year= 2005 |pmid= 15500908 |doi= 10.1016/j.pharmthera.2004.08.002
*cite journal | author=Wu H, Zhou Y, Xiong ZQ |title=Transducer of regulated CREB and late phase long-term synaptic potentiation. |journal=FEBS J. |volume=274 |issue= 13 |pages= 3218–23 |year= 2007 |pmid= 17565597 |doi= 10.1111/j.1742-4658.2007.05891.x
*cite journal | author=Kitagawa K |title=CREB and cAMP response element-mediated gene expression in the ischemic brain. |journal=FEBS J. |volume=274 |issue= 13 |pages= 3210–7 |year= 2007 |pmid= 17565598 |doi= 10.1111/j.1742-4658.2007.05890.x
*cite journal | author=Takemori H, Kajimura J, Okamoto M |title=TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain. |journal=FEBS J. |volume=274 |issue= 13 |pages= 3202–9 |year= 2007 |pmid= 17565599 |doi= 10.1111/j.1742-4658.2007.05889.x
*cite journal | author=Siu YT, Jin DY |title=CREB--a real culprit in oncogenesis. |journal=FEBS J. |volume=274 |issue= 13 |pages= 3224–32 |year= 2007 |pmid= 17565603 |doi= 10.1111/j.1742-4658.2007.05884.x

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • CREB — redirects here. For other uses, see Clean Renewable Energy Bonds. CREB (top) is a transcription factor capable of binding DNA (bottom) and regulating gene expression. CREB (cAMP response element binding) is a cellular transcription factor. It… …   Wikipedia

  • SUMO network — consists of enzymes and substrates involved in the dynamic posttranslational modification process of sumoylation (i.e. transfer of SUMO protein to substrates). Network membersThe SUMO network members (gene name and aliases) as published in the… …   Wikipedia

  • Down syndrome — Classification and external resources Boy with Down syndrome assembling a …   Wikipedia

  • BZIP domain — Pfam box Symbol = bZIP 1 Name = bZIP transcription factor width =220 caption =CREB (top) is a transcription factor capable of binding DNA via the bZIP domain (bottom) and regulating gene expression. Pfam= PF00170 InterPro= IPR011616 SMART=… …   Wikipedia

  • MECP2 — Methyl CpG binding protein 2 (Rett syndrome) PDB rendering based on 1qk9 …   Wikipedia

  • Transcription coregulator — In the field of molecular biology, transcription coregulators are proteins that interact with transcription factors to either activate or repress the transcription of specific genes.cite journal |author=Glass CK, Rosenfeld MG|title=The… …   Wikipedia

  • CEBPB — CCAAT/enhancer binding protein (C/EBP), beta PDB rendering based on 1ci6 …   Wikipedia

  • DNA polymerase beta — Polymerase (DNA directed), beta PDB rendering based on 1bno …   Wikipedia

  • PRKAR2B — Protein kinase, cAMP dependent, regulatory, type II, beta, also known as PRKAR2B, is a human gene.cite web | title = Entrez Gene: PRKAR2B protein kinase, cAMP dependent, regulatory, type II, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db …   Wikipedia

  • RPS6KA4 — Ribosomal protein S6 kinase, 90kDa, polypeptide 4, also known as RPS6KA4, is a human gene.cite web | title = Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.