HIF1A


HIF1A

Hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), also known as HIF1A, is a human gene. PBB_Summary
section_title =
summary_text = The protein encoded by HIF1 is a bHLH-PAS transcription factor found in mammalian cells growing at low oxygen concentrations. It plays an essential role in cellular and systemic responses to hypoxia. [cite journal | author=Ratcliffe PJ |title=From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway. |journal=Blood Purif. |volume=20 |issue= 5 |pages= 445–50 |year= 2003 |pmid= 12207089 |doi=10.1159/000065201] This is one of the class of hypoxia inducible factors, a family that includes Hif1a, Hif2a, and Hif3a.

HIF1 is a heterodimer composed of Hif1a, the alpha subunit, and the aryl hydrocarbon receptor nuclear translocator (Arnt), the beta subunit. Overexpression of a natural antisense transcript (aHIF) of this gene is associated with nonpapillary renal carcinomas. [cite journal | author=Quintero M, Mackenzie N, Brennan PA |title=Hypoxia-inducible factor 1 (HIF-1) in cancer. |journal=Eur J Surg Oncol |volume=30 |issue= 5 |pages= 465–8 |year= 2004 |pmid= 15135470 |doi= 10.1016/j.ejso.2004.03.008] Two alternative transcripts encoding different isoforms have been identified. [cite web | title = Entrez Gene: HIF1A hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3091| accessdate = ]

ee also

* Hypoxia inducible factors

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Semenza GL |title=HIF-1 and human disease: one highly involved factor. |journal=Genes Dev. |volume=14 |issue= 16 |pages= 1983–91 |year= 2000 |pmid= 10950862 |doi=
*cite journal | author=Semenza G |title=Signal transduction to hypoxia-inducible factor 1. |journal=Biochem. Pharmacol. |volume=64 |issue= 5-6 |pages= 993–8 |year= 2002 |pmid= 12213597 |doi=
*cite journal | author=Arbeit JM |title=Quiescent hypervascularity mediated by gain of HIF-1 alpha function. |journal=Cold Spring Harb. Symp. Quant. Biol. |volume=67 |issue= |pages= 133–42 |year= 2003 |pmid= 12858534 |doi=
*cite journal | author=Sitkovsky M, Lukashev D |title=Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors. |journal=Nat. Rev. Immunol. |volume=5 |issue= 9 |pages= 712–21 |year= 2005 |pmid= 16110315 |doi= 10.1038/nri1685
*cite journal | author=Mobasheri A, Richardson S, Mobasheri R, "et al." |title=Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes. |journal=Histol. Histopathol. |volume=20 |issue= 4 |pages= 1327–38 |year= 2006 |pmid= 16136514 |doi=
*cite journal | author=Schipani E |title=Hypoxia and HIF-1 alpha in chondrogenesis. |journal=Semin. Cell Dev. Biol. |volume=16 |issue= 4-5 |pages= 539–46 |year= 2006 |pmid= 16144691 |doi= 10.1016/j.semcdb.2005.03.003
*cite journal | author=Haase VH |title=Hypoxia-inducible factors in the kidney. |journal=Am. J. Physiol. Renal Physiol. |volume=291 |issue= 2 |pages= F271–81 |year= 2006 |pmid= 16554418 |doi= 10.1152/ajprenal.00071.2006
*cite journal | author=Liang D, Kong X, Sang N |title=Effects of histone deacetylase inhibitors on HIF-1. |journal=Cell Cycle |volume=5 |issue= 21 |pages= 2430–5 |year= 2007 |pmid= 17102633 |doi=

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