CEBPE


CEBPE

CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CHOP, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene.cite web | title = Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1053| accessdate = ] cite journal | author = Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG | title = A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus | journal = Genomics | volume = 35 | issue = 1 | pages = 30–8 | year = 1996 | month = July | pmid = 8661101 | doi = 10.1006/geno.1996.0319 | url = | issn = ] It is pro-apoptotic.cite journal | author = Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M | title = N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation | journal = J. Biol. Chem. | volume = 281 | issue = 20 | pages = 14494–502 | year = 2006 | month = May | pmid = 16531405 | doi = 10.1074/jbc.M600575200 | url = | issn = ]

The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.cite web | title = Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1053| accessdate = ]

References

Further reading

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citations =
*cite journal | author=Sladek FM, Darnell JE |title=Mechanisms of liver-specific gene expression. |journal=Curr. Opin. Genet. Dev. |volume=2 |issue= 2 |pages= 256–9 |year= 1992 |pmid= 1638120 |doi=
*cite journal | author=Gombart AF, Koeffler HP |title=Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon). |journal=Curr. Opin. Hematol. |volume=9 |issue= 1 |pages= 36–42 |year= 2002 |pmid= 11753076 |doi=
*cite journal | author=Williams SC, Cantwell CA, Johnson PF |title=A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. |journal=Genes Dev. |volume=5 |issue= 9 |pages= 1553–67 |year= 1991 |pmid= 1884998 |doi=
*cite journal | author=Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG |title=A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus. |journal=Genomics |volume=35 |issue= 1 |pages= 30–8 |year= 1996 |pmid= 8661101 |doi=
*cite journal | author=Chumakov AM, Grillier I, Chumakova E, "et al." |title=Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor. |journal=Mol. Cell. Biol. |volume=17 |issue= 3 |pages= 1375–86 |year= 1997 |pmid= 9032264 |doi=
*cite journal | author=Yamanaka R, Kim GD, Radomska HS, "et al." |title=CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 12 |pages= 6462–7 |year= 1997 |pmid= 9177240 |doi=
*cite journal | author=Verbeek W, Gombart AF, Chumakov AM, "et al." |title=C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters. |journal=Blood |volume=93 |issue= 10 |pages= 3327–37 |year= 1999 |pmid= 10233885 |doi=
*cite journal | author=Lekstrom-Himes JA, Dorman SE, Kopar P, "et al." |title=Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon. |journal=J. Exp. Med. |volume=189 |issue= 11 |pages= 1847–52 |year= 1999 |pmid= 10359588 |doi=
*cite journal | author=Tavor S, Vuong PT, Park DJ, "et al." |title=Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice. |journal=Blood |volume=99 |issue= 5 |pages= 1794–801 |year= 2002 |pmid= 11861297 |doi=
*cite journal | author=Zhang P, Nelson E, Radomska HS, "et al." |title=Induction of granulocytic differentiation by 2 pathways. |journal=Blood |volume=99 |issue= 12 |pages= 4406–12 |year= 2002 |pmid= 12036869 |doi=
*cite journal | author=Kim J, Cantwell CA, Johnson PF, "et al." |title=Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38037–44 |year= 2002 |pmid= 12161447 |doi= 10.1074/jbc.M207235200
*cite journal | author=Du J, Stankiewicz MJ, Liu Y, "et al." |title=Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43481–94 |year= 2003 |pmid= 12202480 |doi= 10.1074/jbc.M204777200
*cite journal | author=Truong BT, Lee YJ, Lodie TA, "et al." |title=CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia. |journal=Blood |volume=101 |issue= 3 |pages= 1141–8 |year= 2003 |pmid= 12393450 |doi= 10.1182/blood-2002-05-1374
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gombart AF, Kwok SH, Anderson KL, "et al." |title=Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1. |journal=Blood |volume=101 |issue= 8 |pages= 3265–73 |year= 2003 |pmid= 12515729 |doi= 10.1182/blood-2002-04-1039
*cite journal | author=Khanna-Gupta A, Zibello T, Sun H, "et al." |title=Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and C/EBP epsilon ) and CDP/cut in myeloid maturation-induced lactoferrin gene expression. |journal=Blood |volume=101 |issue= 9 |pages= 3460–8 |year= 2003 |pmid= 12522000 |doi= 10.1182/blood-2002-09-2767
*cite journal | author=Gery S, Gombart AF, Fung YK, Koeffler HP |title=C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis. |journal=Blood |volume=103 |issue= 3 |pages= 828–35 |year= 2004 |pmid= 12947005 |doi= 10.1182/blood-2003-01-0159
*cite journal | author=Gery S, Park DJ, Vuong PT, "et al." |title=Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes. |journal=Blood |volume=104 |issue= 13 |pages= 3911–7 |year= 2005 |pmid= 15308577 |doi= 10.1182/blood-2003-10-3688

External links

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