- Leucine zipper
helical wheeldiagram, of a leucine zipper, where d represent amino acid leucine , arranged with other amino acidson two parallel alpha helices.]
A leucine zipper, aka leucine scissors [cite encyclopedia | editor = David M. Glick| encyclopedia = Glossary of Biochemistry and Molecular Biology | title = Leucine scissors | edition = Revised | year = 1997 | publisher = Portland Press | volume = | location = London | quote = ] , is a super secondary
structural motiffound in proteinsthat creates adhesion forces in parallel alpha helices. It is a common dimerization domain found in some proteins involved in regulating gene expression.
The main feature of the leucine zipper domain is the predominance of the common
amino acid leucineat the "d" position of the heptad repeat. Leucine zippers were first identified by sequence alignmentof certain transcription factors which identified a common pattern of leucines every seven amino acids. These leucines were later shown to form the hydrophobic coreof a coiled coil.
Each half of a leucine zipper consists of a short
alpha-helixwith a leucine residue at every seventh position. The standard 3.6 residues per turn alpha-helix structure changes slightly to become a 3.5 residues per turn alpha-helix. Known also as the heptat repeat, one leucine comes in direct contact with another leucine on the other strand every second turn.
The bZip family of transcription factors consist of a basic region which interacts with the
major grooveof a DNAmolecule through hydrogen bonding, and a hydrophobicleucine zipper region which is responsible for dimerization.
Leucine zipper regulatory proteins include
c-fosand c-jun(the AP1 transcription factor), important regulators of normal development. If they are overproduced or mutated in a vital area, they may generate cancer. These proteins interact with the DNA as dimers (homo- or hetero-) and are also called basic zipper proteins (bZips).
* Landschulz WH, Johnson PF, McKnight SL. (1988) The leucine zipper: a hypothetical structure common to a new class of DNA-binding proteins. "Science" 240:1759-1764. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3289117&query_hl=5 PubMed abstract]
Wikimedia Foundation. 2010.
Look at other dictionaries:
leucine zipper — leucine zipper. См. лейциновая молния. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) … Молекулярная биология и генетика. Толковый словарь.
Leucine zipper — Domaine « leucine zipper » fixé à un brin d ADN ; les leucines sont colorées en rouge, on voit l interaction de leur radicaux isobutane. Un domaine leucine zipper (de l anglais, signifiant littéralement « fermeture éclair à… … Wikipédia en Français
leucine zipper — Motif found in certain DNA binding proteins. In a region of around 35 amino acids, every seventh is a leucine. This facilitates dimerisation of two such proteins to form a functional transcription factor. Examples of proteins containing leucine… … Dictionary of molecular biology
leucine zipper — a stretch of amino acids consisting of four to seven leucine residues, each separated by six amino acids, occurring adjacent to a highly basic stretch of amino acids in some DNA binding proteins. The configuration of the region is a helix,… … Medical dictionary
Basic Leucine Zipper Domain — CREB (top) ist ein Transkriptionsfaktor, der mit der bZip Domäne ein Dimer formt Die bZIP Domäne, auch Leucin Zipper genannt, ist eine Proteindomäne, die sich in vielen eukaryotischen DNA Bindeproteinen findet sowie der Dimerisierung von… … Deutsch Wikipedia
Basic helix-loop-helix leucine zipper transcription factors — are, as their name indicates, transcription factors containing both Basic helix loop helix and leucine zipper motifs.An example is Microphthalmia associated transcription factor.External links* … Wikipedia
basic leucine zipper — (= bZIP) Family of proteins having a basic region and a leucine zipper. The basic region is the DNA binding domain and the leucine zipper is involved in protein protein interactions to form homo or heterodimers. Includes AP 1, ATF and CREB… … Dictionary of molecular biology
Leucine — L ou S(+) leucine D ou R( ) leucine Général … Wikipédia en Français
Leucine-rich repeat — Pfam box Symbol = LRR 1 Name = width = caption = An example of a leucine rich repeat protein, a porcine ribonuclease inhibitor Pfam= PF00560 InterPro= IPR001611 SMART= Prosite = SCOP = 1bnh TCDB = OPM family= OPM protein= 1xwd PDB=PDB3|1ogqA:155… … Wikipedia
zipper — See leucine zipper … Dictionary of molecular biology