SRY (sex determining region Y)-box 18, also known as SOX18, is a human gene.cite web | title = Entrez Gene: SOX18 SRY (sex determining region Y)-box 18| url =| accessdate = ]

section_title =
summary_text = This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.cite web | title = Entrez Gene: SOX18 SRY (sex determining region Y)-box 18| url =| accessdate = ]

ee also

* SOX genes


Further reading

citations =
*cite journal | author=Wilson M, Koopman P |title=Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators. |journal=Curr. Opin. Genet. Dev. |volume=12 |issue= 4 |pages= 441–6 |year= 2003 |pmid= 12100890 |doi=
*cite journal | author=Schepers GE, Teasdale RD, Koopman P |title=Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. |journal=Dev. Cell |volume=3 |issue= 2 |pages= 167–70 |year= 2002 |pmid= 12194848 |doi=
*cite journal | author=Denny P, Swift S, Brand N, "et al." |title=A conserved family of genes related to the testis determining gene, SRY. |journal=Nucleic Acids Res. |volume=20 |issue= 11 |pages= 2887 |year= 1992 |pmid= 1614875 |doi=
*cite journal | author=Dunn TL, Mynett-Johnson L, Wright EM, "et al." |title=Sequence and expression of Sox-18 encoding a new HMG-box transcription factor. |journal=Gene |volume=161 |issue= 2 |pages= 223–5 |year= 1995 |pmid= 7665083 |doi=
*cite journal | author=Azuma T, Seki N, Yoshikawa T, "et al." |title=cDNA cloning, tissue expression, and chromosome mapping of human homolog of SOX18. |journal=J. Hum. Genet. |volume=45 |issue= 3 |pages= 192–5 |year= 2000 |pmid= 10807548 |doi=
*cite journal | author=Stanojcić S, Stevanović M |title=The human SOX18 gene: cDNA cloning and high resolution mapping. |journal=Biochim. Biophys. Acta |volume=1492 |issue= 1 |pages= 237–41 |year= 2000 |pmid= 10858556 |doi=
*cite journal | author=Pennisi DJ, James KM, Hosking B, "et al." |title=Structure, mapping, and expression of human SOX18. |journal=Mamm. Genome |volume=11 |issue= 12 |pages= 1147–9 |year= 2001 |pmid= 11130989 |doi=
*cite journal | author=Hosking BM, Wang SC, Chen SL, "et al." |title=SOX18 directly interacts with MEF2C in endothelial cells. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 2 |pages= 493–500 |year= 2001 |pmid= 11554755 |doi= 10.1006/bbrc.2001.5589
*cite journal | author=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021–8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Saitoh T, Katoh M |title=Expression of human SOX18 in normal tissues and tumors. |journal=Int. J. Mol. Med. |volume=10 |issue= 3 |pages= 339–44 |year= 2003 |pmid= 12165811 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Irrthum A, Devriendt K, Chitayat D, "et al." |title=Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia. |journal=Am. J. Hum. Genet. |volume=72 |issue= 6 |pages= 1470–8 |year= 2003 |pmid= 12740761 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=García-Ramírez M, Martínez-González J, Juan-Babot JO, "et al." |title=Transcription factor SOX18 is expressed in human coronary atherosclerotic lesions and regulates DNA synthesis and vascular cell growth. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=25 |issue= 11 |pages= 2398–403 |year= 2006 |pmid= 16179596 |doi= 10.1161/01.ATV.0000187464.81959.23
*cite journal | author=Young N, Hahn CN, Poh A, "et al." |title=Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. |journal=J. Natl. Cancer Inst. |volume=98 |issue= 15 |pages= 1060–7 |year= 2006 |pmid= 16882943 |doi= 10.1093/jnci/djj299

External links


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