Kruppel-like factor 5 (intestinal), also known as KLF5, is a human gene.cite web | title = Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=688| accessdate = ]

section_title =
summary_text = This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.cite web | title = Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=688| accessdate = ]

ee also

* Kruppel-like factors


Further reading

citations =
*cite journal | author=Ghaleb AM, Nandan MO, Chanchevalap S, "et al." |title=Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation. |journal=Cell Res. |volume=15 |issue= 2 |pages= 92–6 |year= 2005 |pmid= 15740636 |doi= 10.1038/sj.cr.7290271
*cite journal | author=Nagai R, Suzuki T, Aizawa K, "et al." |title=Significance of the transcription factor KLF5 in cardiovascular remodeling. |journal=J. Thromb. Haemost. |volume=3 |issue= 8 |pages= 1569–76 |year= 2005 |pmid= 16102021 |doi= 10.1111/j.1538-7836.2005.01366.x
*cite journal | author=McConnell BB, Ghaleb AM, Nandan MO, Yang VW |title=The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology. |journal=Bioessays |volume=29 |issue= 6 |pages= 549–57 |year= 2007 |pmid= 17508399 |doi= 10.1002/bies.20581
*cite journal | author=Sogawa K, Imataka H, Yamasaki Y, "et al." |title=cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. |journal=Nucleic Acids Res. |volume=21 |issue= 7 |pages= 1527–32 |year= 1993 |pmid= 8479902 |doi=
*cite journal | author=Kojima S, Kobayashi A, Gotoh O, "et al." |title=Transcriptional activation domain of human BTEB2, a GC box-binding factor. |journal=J. Biochem. |volume=121 |issue= 2 |pages= 389–96 |year= 1997 |pmid= 9089417 |doi=
*cite journal | author=Conkright MD, Wani MA, Anderson KP, Lingrel JB |title=A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells. |journal=Nucleic Acids Res. |volume=27 |issue= 5 |pages= 1263–70 |year= 1999 |pmid= 9973612 |doi=
*cite journal | author=Shi H, Zhang Z, Wang X, "et al." |title=Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter. |journal=Nucleic Acids Res. |volume=27 |issue= 24 |pages= 4807–15 |year= 2000 |pmid= 10572182 |doi=
*cite journal | author=Hoshino Y, Kurabayashi M, Kanda T, "et al." |title=Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis. |journal=Circulation |volume=102 |issue= 20 |pages= 2528–34 |year= 2000 |pmid= 11076828 |doi=
*cite journal | author=Sun R, Chen X, Yang VW |title=Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation. |journal=J. Biol. Chem. |volume=276 |issue= 10 |pages= 6897–900 |year= 2001 |pmid= 11152667 |doi= 10.1074/jbc.C000870200
*cite journal | author=Dang DT, Zhao W, Mahatan CS, "et al." |title=Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene. |journal=Nucleic Acids Res. |volume=30 |issue= 13 |pages= 2736–41 |year= 2002 |pmid= 12087155 |doi=
*cite journal | author=Shindo T, Manabe I, Fukushima Y, "et al." |title=Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. |journal=Nat. Med. |volume=8 |issue= 8 |pages= 856–63 |year= 2002 |pmid= 12101409 |doi= 10.1038/nm738
*cite journal | author=Sur I, Undén AB, Toftgård R |title=Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles. |journal=Eur. J. Cell Biol. |volume=81 |issue= 6 |pages= 323–34 |year= 2003 |pmid= 12113473 |doi=
*cite journal | author=Chen C, Bhalala HV, Qiao H, Dong JT |title=A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer. |journal=Oncogene |volume=21 |issue= 43 |pages= 6567–72 |year= 2002 |pmid= 12242654 |doi= 10.1038/sj.onc.1205817
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yang XO, Doty RT, Hicks JS, Willerford DM |title=Regulation of T-cell receptor D beta 1 promoter by KLF5 through reiterated GC-rich motifs. |journal=Blood |volume=101 |issue= 11 |pages= 4492–9 |year= 2003 |pmid= 12576331 |doi= 10.1182/blood-2002-08-2579
*cite journal | author=Chen C, Bhalala HV, Vessella RL, Dong JT |title=KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer. |journal=Prostate |volume=55 |issue= 2 |pages= 81–8 |year= 2003 |pmid= 12661032 |doi= 10.1002/pros.10205
*cite journal | author=Zhang Z, Teng CT |title=Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function. |journal=Nucleic Acids Res. |volume=31 |issue= 8 |pages= 2196–208 |year= 2003 |pmid= 12682370 |doi=
*cite journal | author=Ohnishi S, Ohnami S, Laub F, "et al." |title=Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 2 |pages= 251–6 |year= 2003 |pmid= 12901861 |doi=
*cite journal | author=Aizawa K, Suzuki T, Kada N, "et al." |title=Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB. |journal=J. Biol. Chem. |volume=279 |issue= 1 |pages= 70–6 |year= 2004 |pmid= 14573617 |doi= 10.1074/jbc.M306621200
*cite journal | author=Sato T, Kanda T, Iida T, "et al." |title=Immunohistochemical study of surgically excised choroidal neovascular membranes. |journal=J. Int. Med. Res. |volume=31 |issue= 5 |pages= 402–6 |year= 2004 |pmid= 14587307 |doi=

External links


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