NFATC4


NFATC4
Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
Identifiers
Symbols NFATC4; NF-ATc4; NFAT3
External IDs OMIM602699 MGI1920431 HomoloGene3349 GeneCards: NFATC4 Gene
RNA expression pattern
PBB GE NFATC4 213345 at tn.png
PBB GE NFATC4 205897 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4776 73181
Ensembl ENSG00000100968 ENSMUSG00000023411
UniProt Q14934 n/a
RefSeq (mRNA) NM_001136022.1 NM_023699
RefSeq (protein) NP_001129494.1 NP_076188
Location (UCSC) Chr 14:
24.83 – 24.85 Mb
Chr 14:
56.44 – 56.45 Mb
PubMed search [1] [2]

Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.[1][2]

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.[2]
NFAT transcription factors are implicated in breast cancer, more specifically in the process of cell motility at the basis of metastasis formation. Indeed NFAT3 (NFATc4) is an inhibitor of cell motility by blocking the expression of LCN2 [3].

Contents

Interactions

NFATC4 has been shown to interact with CREB-binding protein.[4]

See also

References

  1. ^ Hoey T, Sun YL, Williamson K, Xu X (Jun 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID 7749981. 
  2. ^ a b "Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4776. 
  3. ^ Fougère, M; Gaudineau, B, Barbier, J, Guaddachi, F, Feugeas, JP, Auboeuf, D, Jauliac, S (2010 Apr 15). "NFAT3 transcription factor inhibits breast cancer cell motility by targeting the Lipocalin 2 gene.". Oncogene 29 (15): 2292–301. PMID 20101218. 
  4. ^ Yang, T; Davis R J, Chow C W (Oct. 2001). "Requirement of two NFATc4 transactivation domains for CBP potentiation". J. Biol. Chem. (United States) 276 (43): 39569–76. doi:10.1074/jbc.M102961200. ISSN 0021-9258. PMID 11514544. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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Look at other dictionaries:

  • NFAT — Nuclear factor of activated T cells (NFAT) is a general name applied to a family of transcription factors shown to be important in immune response. One or more members of the NFAT family is expressed in most cells of the immune system. NFAT is… …   Wikipedia

  • NFAT — pour Nuclear factor of activated T cells (facteur nucléaire des lymphocytes T activés) est un ensemble de protéines de la famille des facteurs de transcription impliquée dans la réponse immunitaire. Sommaire 1 Structure 2 Mécanisme d action 3… …   Wikipédia en Français

  • CREB-binding protein — See also: p300 CBP coactivator family CREB binding protein PDB rendering based on 1f81 …   Wikipedia

  • mir-133 microRNA precursor family — Predicted secondary structure and sequence conservation of mir 133 Identifiers Symbol mir 133 Rfam …   Wikipedia

  • LCN2 — Lipocalin 2 PDB rendering based on 1dfv …   Wikipedia

  • NF-AT — NFAT NFAT pour Nuclear factor of activated T cells (facteur nucléaire des lymphocytes T activés) est un ensemble de protéines de la famille des facteurs de transcription impliquée dans la réponse immunitaire. Sommaire 1 Structure 2 Mécanisme d… …   Wikipédia en Français

  • Nuclear factor of activated T-cells — NFAT NFAT pour Nuclear factor of activated T cells (facteur nucléaire des lymphocytes T activés) est un ensemble de protéines de la famille des facteurs de transcription impliquée dans la réponse immunitaire. Sommaire 1 Structure 2 Mécanisme d… …   Wikipédia en Français

  • NF-AT — Bezeichner Gen Name(n) …   Deutsch Wikipedia


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