Single-minded homolog 2 (Drosophila), also known as SIM2, is a human gene.cite web | title = Entrez Gene: SIM2 single-minded homolog 2 (Drosophila)| url =| accessdate = ]

section_title =
summary_text = SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal region. Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypescite web | title = Entrez Gene: SIM2 single-minded homolog 2 (Drosophila)| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Muenke M, Bone LJ, Mitchell HF, "et al." |title=Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome. |journal=Am. J. Hum. Genet. |volume=57 |issue= 5 |pages= 1074–9 |year= 1995 |pmid= 7485157 |doi=
*cite journal | author=Dahmane N, Charron G, Lopes C, "et al." |title=Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 20 |pages= 9191–5 |year= 1995 |pmid= 7568099 |doi=
*cite journal | author=Chen H, Chrast R, Rossier C, "et al." |title=Single-minded and Down syndrome? |journal=Nat. Genet. |volume=10 |issue= 1 |pages= 9–10 |year= 1995 |pmid= 7647800 |doi= 10.1038/ng0595-9
*cite journal | author=Yamaki A, Noda S, Kudoh J, "et al." |title=The mammalian single-minded (SIM) gene: mouse cDNA structure and diencephalic expression indicate a candidate gene for Down syndrome. |journal=Genomics |volume=35 |issue= 1 |pages= 136–43 |year= 1996 |pmid= 8661114 |doi= 10.1006/geno.1996.0332
*cite journal | author=Fan CM, Kuwana E, Bulfone A, "et al." |title=Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome. |journal=Mol. Cell. Neurosci. |volume=7 |issue= 1 |pages= 1–16 |year= 1996 |pmid= 8812055 |doi= 10.1006/mcne.1996.0001
*cite journal | author=Osoegawa K, Okano S, Kato Y, "et al." |title=A 19-kb CpG island associated with single-minded gene 2 in Down syndrome chromosomal region. |journal=DNA Res. |volume=3 |issue= 3 |pages= 175–9 |year= 1997 |pmid= 8905236 |doi=
*cite journal | author=Probst MR, Fan CM, Tessier-Lavigne M, Hankinson O |title=Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein. |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4451–7 |year= 1997 |pmid= 9020169 |doi=
*cite journal | author=Chrast R, Scott HS, Chen H, "et al." |title=Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region. |journal=Genome Res. |volume=7 |issue= 6 |pages= 615–24 |year= 1997 |pmid= 9199934 |doi=
*cite journal | author=Moffett P, Reece M, Pelletier J |title=The murine Sim-2 gene product inhibits transcription by active repression and functional interference. |journal=Mol. Cell. Biol. |volume=17 |issue= 9 |pages= 4933–47 |year= 1997 |pmid= 9271372 |doi=
*cite journal | author=Dahmane N, Ghezala GA, Gosset P, "et al." |title=Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome. |journal=Genomics |volume=48 |issue= 1 |pages= 12–23 |year= 1998 |pmid= 9503011 |doi= 10.1006/geno.1997.5146
*cite journal | author=Ema M, Ikegami S, Hosoya T, "et al." |title=Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: an animal model of Down's syndrome. |journal=Hum. Mol. Genet. |volume=8 |issue= 8 |pages= 1409–15 |year= 1999 |pmid= 10400987 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Yamaki A, Tochigi J, Kudoh J, "et al." |title=Molecular mechanisms of human single-minded 2 (SIM2) gene expression: identification of a promoter site in the SIM2 genomic sequence. |journal=Gene |volume=270 |issue= 1-2 |pages= 265–75 |year= 2001 |pmid= 11404025 |doi=
*cite journal | author=Woods SL, Whitelaw ML |title=Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10236–43 |year= 2002 |pmid= 11782478 |doi= 10.1074/jbc.M110752200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Deyoung MP, Scheurle D, Damania H, "et al." |title=Down's syndrome-associated single minded gene as a novel tumor marker. |journal=Anticancer Res. |volume=22 |issue= 6A |pages= 3149–57 |year= 2003 |pmid= 12530058 |doi=
*cite journal | author=DeYoung MP, Tress M, Narayanan R |title=Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4760–5 |year= 2003 |pmid= 12676991 |doi= 10.1073/pnas.0831000100
*cite journal | author=DeYoung MP, Tress M, Narayanan R |title=Down's syndrome-associated Single Minded 2 gene as a pancreatic cancer drug therapy target. |journal=Cancer Lett. |volume=200 |issue= 1 |pages= 25–31 |year= 2003 |pmid= 14550949 |doi=
*cite journal | author=Yamaki A, Kudoh J, Shimizu N, Shimizu Y |title=A novel nuclear localization signal in the human single-minded proteins SIM1 and SIM2. |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 482–8 |year= 2004 |pmid= 14697214 |doi=
*cite journal | author=Ooe N, Saito K, Mikami N, "et al." |title=Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. |journal=Mol. Cell. Biol. |volume=24 |issue= 2 |pages= 608–16 |year= 2004 |pmid= 14701734 |doi=

update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • SIM1 — Single minded homolog 1 (Drosophila), also known as SIM1, is a human gene.cite web | title = Entrez Gene: SIM1 single minded homolog 1 (Drosophila)| url = Cmd=ShowDetailView TermToSearch=6492|… …   Wikipedia

  • Aryl hydrocarbon receptor nuclear translocator — PDB rendering based on 1x0o …   Wikipedia

  • SUMO network — consists of enzymes and substrates involved in the dynamic posttranslational modification process of sumoylation (i.e. transfer of SUMO protein to substrates). Network membersThe SUMO network members (gene name and aliases) as published in the… …   Wikipedia

  • Non-interactive zero-knowledge proof — Non interactive zero knowledge proofs are a variant of zero knowledge proofs. Blum, Feldman, and Micali [1] showed that a common reference string shared between the prover and the verifier is enough to achieve computational zero knowledge without …   Wikipedia

  • Vodafone New Zealand — STK (pre SIM2 ) SIM card, circa 2002 compared with 1996 5¢ coin. Vodafone New Zealand is New Zealand s largest mobile phone operator, based in Auckland. The company was formed in 1998, after Vodafone purchased BellSouth s New Zealand operations.… …   Wikipedia

  • Seleco — Sèleco is an electronics company based in Pordenone, Friuli Venezia Giulia. It is part of Super//Fluo, who bought the rights in August, 2006, along with Brionvega and Imperial.HistorySèleco was born as in 1965 as a spin off from the home… …   Wikipedia

  • Brionvega — is an Italian electronics company, established in Milan in 1945, now located in Pordenone, Friuli Venezia Giulia, Italy.Former part of the Seleco Formenti Group, after the crack down of the company, following price dumping from turkish… …   Wikipedia

  • EPAS1 — Endothelial PAS domain protein 1, also known as EPAS1, is a human gene. [cite web | title = Entrez Gene: EPAS1 endothelial PAS domain protein 1| url = Cmd=ShowDetailView TermToSearch=2034|… …   Wikipedia

  • ARNT2 — Aryl hydrocarbon receptor nuclear translocator 2, also known as ARNT2, is a human gene.cite web | title = Entrez Gene: ARNT2 aryl hydrocarbon receptor nuclear translocator 2| url =… …   Wikipedia

  • Graffeur — Graffiti Pour les articles homonymes, voir Graffiti (homonymie). Inscription espagnole au El Morro National Monument, 1605, avec des graffitis ultérieurs …   Wikipédia en Français

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.