PITX1

PITX1

Paired-like homeodomain transcription factor 1, also known as PITX1, is a human gene.cite web | title = Entrez Gene: PITX1 paired-like homeodomain transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5307| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin cite web | title = Entrez Gene: PITX1 paired-like homeodomain transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5307| accessdate = ] and it could be associated with autism [Citation
pmid = :18053270
url=http://www.ncbi.nlm.nih.gov/pubmed/18053270
last=Philippi
first=Anne
last2=Tores
first2=Frédéric
last3=Carayol
first3=Jérome
last4=Rousseau
first4=Francis
publication-date=2007
year=2007
title=Association of autism with polymorphisms in the paired-like homeodomain transcription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis.
volume=8
issue=
periodical=BMC Med. Genet.
pages=741471-2350-8-74
doi = 10.1186/1471-2350-8-7418053270
]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG |title=P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 15 |pages= 7706–10 |year= 1996 |pmid= 8755540 |doi=
*cite journal | author=Shang J, Li X, Ring HZ, "et al." |title=Backfoot, a novel homeobox gene, maps to human chromosome 5 (BFT) and mouse chromosome 13 (Bft). |journal=Genomics |volume=40 |issue= 1 |pages= 108–13 |year= 1997 |pmid= 9070926 |doi= 10.1006/geno.1996.4558
*cite journal | author=Shang J, Luo Y, Clayton DA |title=Backfoot is a novel homeobox gene expressed in the mesenchyme of developing hind limb. |journal=Dev. Dyn. |volume=209 |issue= 2 |pages= 242–53 |year= 1997 |pmid= 9186059 |doi= 10.1002/(SICI)1097-0177(199706)209:2<242::AID-AJA10>3.0.CO;2-0 |doilabel=10.1002/(SICI)1097-0177(199706)209:2242::AID-AJA103.0.CO;2-0
*cite journal | author=Crawford MJ, Lanctôt C, Tremblay JJ, "et al." |title=Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome. |journal=Mamm. Genome |volume=8 |issue= 11 |pages= 841–5 |year= 1998 |pmid= 9337397 |doi=
*cite journal | author=Poulin G, Turgeon B, Drouin J |title=NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6673–82 |year= 1997 |pmid= 9343431 |doi=
*cite journal | author=Tremblay JJ, Drouin J |title=Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcription. |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 2567–76 |year= 1999 |pmid= 10082522 |doi=
*cite journal | author=Tremblay JJ, Marcil A, Gauthier Y, Drouin J |title=Ptx1 regulates SF-1 activity by an interaction that mimics the role of the ligand-binding domain. |journal=EMBO J. |volume=18 |issue= 12 |pages= 3431–41 |year= 1999 |pmid= 10369682 |doi= 10.1093/emboj/18.12.3431
*cite journal | author=Pellegrini-Bouiller I, Manrique C, Gunz G, "et al." |title=Expression of the members of the Ptx family of transcription factors in human pituitary adenomas. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 6 |pages= 2212–20 |year= 1999 |pmid= 10372733 |doi=
*cite journal | author=Tahara S, Kurotani R, Sanno N, "et al." |title=Expression of pituitary homeo box 1 (Ptx1) in human non-neoplastic pituitaries and pituitary adenomas. |journal=Mod. Pathol. |volume=13 |issue= 10 |pages= 1097–108 |year= 2001 |pmid= 11048804 |doi= 10.1038/modpathol.3880204
*cite journal | author=Quentien MH, Manfroid I, Moncet D, "et al." |title=Pitx factors are involved in basal and hormone-regulated activity of the human prolactin promoter. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44408–16 |year= 2003 |pmid= 12223489 |doi= 10.1074/jbc.M207824200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ghosh AK, Majumder M, Steele R, "et al." |title=Modulation of interferon expression by hepatitis C virus NS5A protein and human homeodomain protein PTX1. |journal=Virology |volume=306 |issue= 1 |pages= 51–9 |year= 2003 |pmid= 12620797 |doi=
*cite journal | author=Hiroi N, Kino T, Bassett M, "et al." |title=Pituitary homeobox factor 1, a novel transcription factor in the adrenal regulating steroid 11beta-hydroxylase. |journal=Horm. Metab. Res. |volume=35 |issue= 5 |pages= 273–8 |year= 2004 |pmid= 12915995 |doi= 10.1055/s-2003-41301
*cite journal | author=Schmutz J, Martin J, Terry A, "et al." |title=The DNA sequence and comparative analysis of human chromosome 5. |journal=Nature |volume=431 |issue= 7006 |pages= 268–74 |year= 2004 |pmid= 15372022 |doi= 10.1038/nature02919
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kolfschoten IG, van Leeuwen B, Berns K, "et al." |title=A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. |journal=Cell |volume=121 |issue= 6 |pages= 849–58 |year= 2005 |pmid= 15960973 |doi= 10.1016/j.cell.2005.04.017
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Lord RV, Brabender J, Wickramasinghe K, "et al." |title=Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma. |journal=Surgery |volume=138 |issue= 5 |pages= 924–31 |year= 2006 |pmid= 16291394 |doi= 10.1016/j.surg.2005.05.007
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Picard C, Azeddine B, Moldovan F, "et al." |title=New emerging role of pitx1 transcription factor in osteoarthritis pathogenesis. |journal=Clin. Orthop. Relat. Res. |volume=462 |issue= |pages= 59–66 |year= 2007 |pmid= 17549029 |doi= 10.1097/BLO.0b013e3180d09d9c

External links

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PBB_Controls
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require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


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