FOS-like antigen 1, also known as FOSL1, is a human gene.cite web | title = Entrez Gene: FOSL1 FOS-like antigen 1| url =| accessdate = ]

section_title =
summary_text = The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.cite web | title = Entrez Gene: FOSL1 FOS-like antigen 1| url =| accessdate = ]

ee also

* AP-1 (transcription factor)


Further reading

citations =
*cite journal | author=Herdegen T, Leah JD |title=Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. |journal=Brain Res. Brain Res. Rev. |volume=28 |issue= 3 |pages= 370–490 |year= 1999 |pmid= 9858769 |doi=
*cite journal | author=Reddy SP, Mossman BT |title=Role and regulation of activator protein-1 in toxicant-induced responses of the lung. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=283 |issue= 6 |pages= L1161–78 |year= 2002 |pmid= 12424143 |doi= 10.1152/ajplung.00140.2002
*cite journal | author=Matsui M, Tokuhara M, Konuma Y, "et al." |title=Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. |journal=Oncogene |volume=5 |issue= 3 |pages= 249–55 |year= 1990 |pmid= 2107490 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Tsuchiya H, Fujii M, Niki T, "et al." |title=Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals. |journal=J. Virol. |volume=67 |issue= 12 |pages= 7001–7 |year= 1993 |pmid= 8230424 |doi=
*cite journal | author=Sinke RJ, Tanigami A, Nakamura Y, Geurts van Kessel A |title=Reverse mapping of the gene encoding the human fos-related antigen-1 (fra-1) within chromosome band 11q13. |journal=Genomics |volume=18 |issue= 1 |pages= 165 |year= 1994 |pmid= 8276409 |doi=
*cite journal | author=Courseaux A, Grosgeorge J, Gaudray P, "et al." |title=Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1). |journal=Genomics |volume=37 |issue= 3 |pages= 354–65 |year= 1997 |pmid= 8938448 |doi=
*cite journal | author=Arts J, Herr I, Lansink M, "et al." |title=Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro. |journal=Nucleic Acids Res. |volume=25 |issue= 2 |pages= 311–7 |year= 1997 |pmid= 9016559 |doi=
*cite journal | author=Pognonec P, Boulukos KE, Aperlo C, "et al." |title=Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity. |journal=Oncogene |volume=14 |issue= 17 |pages= 2091–8 |year= 1997 |pmid= 9160889 |doi= 10.1038/sj.onc.1201046
*cite journal | author=Smith CM, Ma NS, Nowak NJ, "et al." |title=A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13. |journal=Genome Res. |volume=7 |issue= 8 |pages= 835–42 |year= 1997 |pmid= 9267807 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Puntschart A, Wey E, Jostarndt K, "et al." |title=Expression of fos and jun genes in human skeletal muscle after exercise. |journal=Am. J. Physiol. |volume=274 |issue= 1 Pt 1 |pages= C129–37 |year= 1998 |pmid= 9458721 |doi=
*cite journal | author=Finzer P, Soto U, Delius H, "et al." |title=Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition. |journal=Oncogene |volume=19 |issue= 29 |pages= 3235–44 |year= 2000 |pmid= 10918580 |doi= 10.1038/sj.onc.1203643
*cite journal | author=Udalova IA, Kwiatkowski D |title=Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 1 |pages= 25–33 |year= 2001 |pmid= 11708771 |doi= 10.1006/bbrc.2001.5929
*cite journal | author=Jardine H, MacNee W, Donaldson K, Rahman I |title=Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21158–66 |year= 2002 |pmid= 11912197 |doi= 10.1074/jbc.M112145200
*cite journal | author=Wang HL, Wang J, Xiao SY, "et al." |title=Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin. |journal=Int. J. Cancer |volume=101 |issue= 4 |pages= 301–10 |year= 2002 |pmid= 12209953 |doi= 10.1002/ijc.10630
*cite journal | author=Bergman MR, Cheng S, Honbo N, "et al." |title=A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. |journal=Biochem. J. |volume=369 |issue= Pt 3 |pages= 485–96 |year= 2003 |pmid= 12371906 |doi= 10.1042/BJ20020707
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

External links


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