Retinoid X receptor beta


Retinoid X receptor beta
Retinoid X receptor, beta

PDB rendering based on 1by4.
Identifiers
Symbols RXRB; DAUDI6; H-2RIIBP; MGC1831; NR2B2; RCoR-1
External IDs OMIM180246 MGI98215 HomoloGene7923 IUPHAR: NR2B2 GeneCards: RXRB Gene
RNA expression pattern
PBB GE RXRB 209148 at tn.png
PBB GE RXRB 215099 s at tn.png
PBB GE RXRB 215098 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6257 20182
Ensembl ENSG00000204231 ENSMUSG00000039656
UniProt P28702 Q3TWJ1
RefSeq (mRNA) NM_021976 NM_011306
RefSeq (protein) NP_068811 NP_035436
Location (UCSC) Chr 6:
33.27 – 33.28 Mb
Chr 17:
34.17 – 34.18 Mb
PubMed search [1] [2]

Retinoid X receptor beta (RXR-beta), also known as NR2B2 (nuclear receptor subfamily 2, group B, member 2) is a nuclear receptor that in humans is encoded by the RXRB gene.[1][2]

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.[2]

See also

References

  1. ^ Fitzgibbon J, Gillett GT, Woodward KJ, Boyle JM, Wolfe J, Povey S (July 1993). "Mapping of RXRB to human chromosome 6p21.3". Ann. Hum. Genet. 57 (Pt 3): 203–9. doi:10.1111/j.1469-1809.1993.tb01596.x. PMID 8257090. 
  2. ^ a b "Entrez Gene: RXRB retinoid X receptor, beta". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6257. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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