Retinoid X receptor gamma


Retinoid X receptor gamma
Retinoid X receptor, gamma

Crystallographic structure of the DNA-binding domain of the Retinoid X receptor, gamma. PDB rendering based on 1by4.
Identifiers
Symbols RXRG; NR2B3; RXRC
External IDs OMIM180247 MGI98216 HomoloGene21373 IUPHAR: NR2B3 GeneCards: RXRG Gene
RNA expression pattern
PBB GE RXRG 205954 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6258 20183
Ensembl ENSG00000143171 ENSMUSG00000015843
UniProt P48443 Q3V193
RefSeq (mRNA) NM_006917.4 NM_009107
RefSeq (protein) NP_001009598 NP_033133
Location (UCSC) Chr 1:
165.37 – 165.41 Mb
Chr 1:
169.53 – 169.57 Mb
PubMed search [1] [2]

Retinoic acid receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor that in humans is encoded by the RXRG gene.[1][2]

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

Contents

See also

Interactions

Retinoid X receptor gamma has been shown to interact with ITGB3BP.[3]

References

  1. ^ Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM (April 1994). "Chromosomal localization of the human retinoid X receptors". Genomics 20 (3): 397–403. doi:10.1006/geno.1994.1193. PMID 8034312. 
  2. ^ a b "Entrez Gene: RXRG retinoid X receptor, gamma". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6258. 
  3. ^ Li, D; Wang F, Samuels H H (Dec. 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. (United States) 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. ISSN 0270-7306. PMC 100002. PMID 11713274. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=100002. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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