Retinoid X receptor gamma

Retinoid X receptor gamma
Retinoid X receptor, gamma

Crystallographic structure of the DNA-binding domain of the Retinoid X receptor, gamma. PDB rendering based on 1by4.
Symbols RXRG; NR2B3; RXRC
External IDs OMIM180247 MGI98216 HomoloGene21373 IUPHAR: NR2B3 GeneCards: RXRG Gene
RNA expression pattern
PBB GE RXRG 205954 at tn.png
More reference expression data
Species Human Mouse
Entrez 6258 20183
Ensembl ENSG00000143171 ENSMUSG00000015843
UniProt P48443 Q3V193
RefSeq (mRNA) NM_006917.4 NM_009107
RefSeq (protein) NP_001009598 NP_033133
Location (UCSC) Chr 1:
165.37 – 165.41 Mb
Chr 1:
169.53 – 169.57 Mb
PubMed search [1] [2]

Retinoic acid receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor that in humans is encoded by the RXRG gene.[1][2]

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]


See also


Retinoid X receptor gamma has been shown to interact with ITGB3BP.[3]


  1. ^ Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM (April 1994). "Chromosomal localization of the human retinoid X receptors". Genomics 20 (3): 397–403. doi:10.1006/geno.1994.1193. PMID 8034312. 
  2. ^ a b "Entrez Gene: RXRG retinoid X receptor, gamma". 
  3. ^ Li, D; Wang F, Samuels H H (Dec. 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. (United States) 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. ISSN 0270-7306. PMC 100002. PMID 11713274. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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