BCL6


BCL6

B-cell CLL/lymphoma 6 (zinc finger protein 51), also known as BCL6, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Two alternatively spliced transcript variants that encode the identical protein have been reported for this gene. [cite web | title = Entrez Gene: BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=604| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ueda C, Akasaka T, Ohno H |title=Non-immunoglobulin/BCL6 gene fusion in diffuse large B-cell lymphoma: prognostic implications. |journal=Leuk. Lymphoma |volume=43 |issue= 7 |pages= 1375–81 |year= 2003 |pmid= 12389616 |doi=
*cite journal | author=Niu H |title=The proto-oncogene BCL-6 in normal and malignant B cell development. |journal=Hematological oncology |volume=20 |issue= 4 |pages= 155–66 |year= 2003 |pmid= 12469325 |doi= 10.1002/hon.689
*cite journal | author=Tokuhisa T |title= [A role for Bcl6 in immune memory development] |journal=Tanpakushitsu Kakusan Koso |volume=47 |issue= 16 Suppl |pages= 2306–12 |year= 2003 |pmid= 12518453 |doi=
*cite journal | author=Ohno H |title=Pathogenetic role of BCL6 translocation in B-cell non-Hodgkin's lymphoma. |journal=Histol. Histopathol. |volume=19 |issue= 2 |pages= 637–50 |year= 2004 |pmid= 15024721 |doi=
*cite journal | author=Pasqualucci L, Bereschenko O, Niu H, "et al." |title=Molecular pathogenesis of non-Hodgkin's lymphoma: the role of Bcl-6. |journal=Leuk. Lymphoma |volume=44 Suppl 3 |issue= |pages= S5–12 |year= 2004 |pmid= 15202519 |doi=
*cite journal | author=Jardin F, Ruminy P, Bastard C, Tilly H |title=The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis. |journal=Pathol. Biol. |volume=55 |issue= 1 |pages= 73–83 |year= 2007 |pmid= 16815642 |doi= 10.1016/j.patbio.2006.04.001

External links

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