Interferon regulatory factor 2, also known as IRF2, is a human gene.

section_title =
summary_text = IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [cite web | title = Entrez Gene: IRF2 interferon regulatory factor 2| url =| accessdate = ]

ee also

*Interferon regulatory factors


Further reading

citations =
*cite journal | author=Harada H, Taniguchi T, Tanaka N |title=The role of interferon regulatory factors in the interferon system and cell growth control. |journal=Biochimie |volume=80 |issue= 8-9 |pages= 641–50 |year= 1999 |pmid= 9865486 |doi=
*cite journal | author=Pitha PM, Au WC, Lowther W, "et al." |title=Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth. |journal=Biochimie |volume=80 |issue= 8-9 |pages= 651–8 |year= 1999 |pmid= 9865487 |doi=
*cite journal | author=Harada H, Fujita T, Miyamoto M, "et al." |title=Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. |journal=Cell |volume=58 |issue= 4 |pages= 729–39 |year= 1989 |pmid= 2475256 |doi=
*cite journal | author=Itoh S, Harada H, Fujita T, "et al." |title=Sequence of a cDNA coding for human IRF-2. |journal=Nucleic Acids Res. |volume=17 |issue= 20 |pages= 8372 |year= 1989 |pmid= 2813069 |doi=
*cite journal | author=Harada H, Takahashi E, Itoh S, "et al." |title=Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system. |journal=Mol. Cell. Biol. |volume=14 |issue= 2 |pages= 1500–9 |year= 1994 |pmid= 7507207 |doi=
*cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, "et al." |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=
*cite journal | author=Sharf R, Azriel A, Lejbkowicz F, "et al." |title=Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors. |journal=J. Biol. Chem. |volume=270 |issue= 22 |pages= 13063–9 |year= 1995 |pmid= 7768900 |doi=
*cite journal | author=Cha Y, Deisseroth AB |title=Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region. |journal=J. Biol. Chem. |volume=269 |issue= 7 |pages= 5279–87 |year= 1994 |pmid= 8106512 |doi=
*cite journal | author=Harada H, Kitagawa M, Tanaka N, "et al." |title=Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2. |journal=Science |volume=259 |issue= 5097 |pages= 971–4 |year= 1993 |pmid= 8438157 |doi=
*cite journal | author=Drew PD, Franzoso G, Carlson LM, "et al." |title=Interferon regulatory factor-2 physically interacts with NF-kappa B in vitro and inhibits NF-kappa B induction of major histocompatibility class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells. |journal=J. Neuroimmunol. |volume=63 |issue= 2 |pages= 157–62 |year= 1996 |pmid= 8550813 |doi=
*cite journal | author=Birnbaum MJ, van Zundert B, Vaughan PS, "et al." |title=Phosphorylation of the oncogenic transcription factor interferon regulatory factor 2 (IRF2) in vitro and in vivo. |journal=J. Cell. Biochem. |volume=66 |issue= 2 |pages= 175–83 |year= 1997 |pmid= 9213219 |doi=
*cite journal | author=Masumi A, Wang IM, Lefebvre B, "et al." |title=The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 1810–20 |year= 1999 |pmid= 10022868 |doi=
*cite journal | author=Li W, Nagineni CN, Hooks JJ, "et al." |title=Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors. |journal=Invest. Ophthalmol. Vis. Sci. |volume=40 |issue= 5 |pages= 976–82 |year= 1999 |pmid= 10102295 |doi=
*cite journal | author=Whitney LW, Becker KG, Tresser NJ, "et al." |title=Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays. |journal=Ann. Neurol. |volume=46 |issue= 3 |pages= 425–8 |year= 1999 |pmid= 10482277 |doi=
*cite journal | author=Mild GC, Schmahl GE, Shayan P, Niemeyer CM |title=Expression of interferon regulatory factor 1 and 2 in hematopoietic cells of children with juvenile myelomonocytic leukemia. |journal=Leuk. Lymphoma |volume=35 |issue= 5-6 |pages= 507–11 |year= 2000 |pmid= 10609788 |doi=
*cite journal | author=Staal A, Enserink JM, Stein JL, "et al." |title=Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2. |journal=J. Cell. Physiol. |volume=185 |issue= 2 |pages= 269–79 |year= 2000 |pmid= 11025449 |doi= 10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L |doilabel=10.1002/1097-4652(200011)185:2269::AID-JCP123.0.CO;2-L
*cite journal | author=Larrea E, Alberdi A, Castelruiz Y, "et al." |title=Expression of interferon-alpha subtypes in peripheral mononuclear cells from patients with chronic hepatitis C: a role for interferon-alpha5. |journal=J. Viral Hepat. |volume=8 |issue= 2 |pages= 103–10 |year= 2001 |pmid= 11264730 |doi=
*cite journal | author=Masumi A, Ozato K |title=Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 20973–80 |year= 2001 |pmid= 11304541 |doi= 10.1074/jbc.M101707200

External links


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