Transcription Factor II H


Transcription Factor II H

protein
Name= general transcription factor IIH, polypeptide 1, 62kDa
caption=


width=
HGNCid=4655
Symbol=GTF2H1
AltSymbols= BTF2
EntrezGene=2965
OMIM=189972
RefSeq=NM_005316
UniProt=P32780
PDB=
ECnumber=
Chromosome=11
Arm=p
Band=15.1
LocusSupplementaryData=-p14
protein
Name=general transcription factor IIH, polypeptide 2, 44kDa
caption=


width=
HGNCid=4656
Symbol=GTF2H2
AltSymbols=BTF2, TFIIH, BTF2P44, T-BTF2P44
EntrezGene=2966
OMIM=601748
RefSeq=NM_001515
UniProt=Q13888
PDB=
ECnumber=
Chromosome=5
Arm=q
Band=12.2
LocusSupplementaryData=-13.3
protein
Name=general transcription factor IIH, polypeptide 3, 34kDa
caption=


width=
HGNCid=4657
Symbol=GTF2H3
AltSymbols=BTF2, TFIIH
EntrezGene=2967
OMIM=601750
RefSeq=NM_001516
UniProt=Q13889
PDB=
ECnumber=
Chromosome=12
Arm=q
Band=24.31
LocusSupplementaryData=

Transcription Factor II H (TFIIH) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. TFIIH contains a number of subunits with different functions.cite journal | author = Lee TI, Young RA | title = Transcription of eukaryotic protein-coding genes | journal = Annu. Rev. Genet. | volume = 34 | issue = | pages = 77–137 | year = 2000 | pmid = 11092823 | doi = 10.1146/annurev.genet.34.1.77] Two of the subunits, ERCC2/XPD and ERCC3/XPB, have helicase and ATPase activities and help create the transcription bubble. In a test tube these subunits are only required for transcription if the DNA template is not already denatured or supercoiled. Two other TFIIH subunits, CDK7 and cyclin H, phosphorylate serine amino acids on the RNA polymerase II C-terminal domain and possibly other proteins involved in the cell cycle.

References

External links

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Look at other dictionaries:

  • Transcription Factor II B — (TFIIB) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.cite book | author = Lewin, Benjamin | title = Genes VIII | publisher = Pearson Prentice Hall | location = Upper Saddle River, NJ |… …   Wikipedia

  • Transcription Factor II D — (TFIID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.cite book | author = Lewin, Benjamin | title = Genes VIII | publisher = Pearson Prentice Hall | location = Upper Saddle River, NJ |… …   Wikipedia

  • transcription factor — n any of various proteins that bind to DNA and play a role in the regulation of gene expression by promoting transcription * * * a protein that regulates gene expression by binding to a DNA sequence adjacent to a sequence encoding a protein or… …   Medical dictionary

  • Transcription factor — In the field of molecular biology, a transcription factor (sometimes called a sequence specific DNA binding factor) is a protein that binds to specific sequences of DNA and thereby controls the transfer (or transcription) of genetic information… …   Wikipedia

  • Transcription Factor II F — protein Name = general transcription factor IIF, polypeptide 1, 74kDa caption = width = HGNCid = 4652 Symbol = GTF2F1 AltSymbols = TFIIF, BTF4, RAP74 EntrezGene = 2962 OMIM = 189968 RefSeq = NM 002096 UniProt = P35269 PDB = ECnumber = Chromosome …   Wikipedia

  • Transcription Factor II A — protein Name = general transcription factor IIA, 1, 19/37kDa caption = width = HGNCid = 4646 Symbol = GTF2A1 AltSymbols = EntrezGene = 2957 OMIM = 600520 RefSeq = NM 201595 UniProt = P52655 PDB = ECnumber = Chromosome = 14 Arm = q Band = 31… …   Wikipedia

  • Transcription Factor II E — protein Name = general transcription factor IIE, polypeptide 1, alpha 56kDa caption = width = HGNCid = 4650 Symbol = GTF2E1 AltSymbols = TF2E1 EntrezGene = 2960 OMIM = 189962 RefSeq = NM 005513 UniProt = P29083 PDB = ECnumber = Chromosome = 3 Arm …   Wikipedia

  • transcription factor — ▪ biology       molecule that controls the activity of a gene by determining whether the gene s DNA (deoxyribonucleic acid) is transcribed into RNA (ribonucleic acid). The enzyme RNA polymerase catalyzes the chemical reactions that synthesize RNA …   Universalium

  • transcription factor — Protein required for recognition by RNA polymerases of specific stimulatory sequences in eukaryotic genes. Several are known that activate transcription by RNA polymerase II when bound to upstream promoters. Transcription of the 5S RNA gene in… …   Dictionary of molecular biology

  • transcription factor — noun Date: 1972 any of various proteins that bind to DNA and play a role in the regulation of gene expression by promoting transcription …   New Collegiate Dictionary


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