Basic helix-loop-helix domain containing, class B, 2, also known as BHLHB2, is a human gene.cite web | title = Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2| url =| accessdate = ]

section_title =
summary_text = DEC1 encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. Differentiated embryo chondrocyte expressed gene 1 is believed to be involved in the control of cell differentiation.cite web | title = Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Shen M, Kawamoto T, Yan W, "et al." |title=Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 2 |pages= 294–8 |year= 1997 |pmid= 9240428 |doi= 10.1006/bbrc.1997.6960
*cite journal | author=Antonevich T, Taneja R |title=Assignment1 of the human Stra13 gene (STRA13) to chromosome 3p26 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=85 |issue= 3-4 |pages= 254–5 |year= 1999 |pmid= 10449910 |doi=
*cite journal | author=Teramoto M, Nakamasu K, Noshiro M, "et al." |title=Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2. |journal=J. Biochem. |volume=129 |issue= 3 |pages= 391–6 |year= 2001 |pmid= 11226878 |doi=
*cite journal | author=Ivanova AV, Ivanov SV, Danilkovitch-Miagkova A, Lerman MI |title=Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 15306–15 |year= 2001 |pmid= 11278694 |doi= 10.1074/jbc.M010516200
*cite journal | author=Sun H, Lu B, Li RQ, "et al." |title=Defective T cell activation and autoimmune disorder in Stra13-deficient mice. |journal=Nat. Immunol. |volume=2 |issue= 11 |pages= 1040–7 |year= 2001 |pmid= 11668339 |doi= 10.1038/ni721
*cite journal | author=Yoon DY, Buchler P, Saarikoski ST, "et al." |title=Identification of genes differentially induced by hypoxia in pancreatic cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 4 |pages= 882–6 |year= 2001 |pmid= 11688991 |doi= 10.1006/bbrc.2001.5867
*cite journal | author=Li Y, Zhang H, Xie M, "et al." |title=Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation. |journal=Biochem. J. |volume=367 |issue= Pt 2 |pages= 413–22 |year= 2002 |pmid= 12119049 |doi= 10.1042/BJ20020514
*cite journal | author=St-Pierre B, Flock G, Zacksenhaus E, Egan SE |title=Stra13 homodimers repress transcription through class B E-box elements. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46544–51 |year= 2003 |pmid= 12297495 |doi= 10.1074/jbc.M111652200
*cite journal | author=Miyazaki K, Kawamoto T, Tanimoto K, "et al." |title=Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47014–21 |year= 2003 |pmid= 12354771 |doi= 10.1074/jbc.M204938200
*cite journal | author=Shen M, Yoshida E, Yan W, "et al." |title=Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 50112–20 |year= 2003 |pmid= 12384505 |doi= 10.1074/jbc.M206771200
*cite journal | author=Honma S, Kawamoto T, Takagi Y, "et al." |title=Dec1 and Dec2 are regulators of the mammalian molecular clock. |journal=Nature |volume=419 |issue= 6909 |pages= 841–4 |year= 2002 |pmid= 12397359 |doi= 10.1038/nature01123
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Li Y, Xie M, Song X, "et al." |title=DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 16899–907 |year= 2003 |pmid= 12624110 |doi= 10.1074/jbc.M300596200
*cite journal | author=Giatromanolaki A, Koukourakis MI, Sivridis E, "et al." |title=DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer. |journal=J. Pathol. |volume=200 |issue= 2 |pages= 222–8 |year= 2003 |pmid= 12754744 |doi= 10.1002/path.1330
*cite journal | author=Ivanova AV, Ivanov SV, Zhang X, "et al." |title=STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets. |journal=J. Mol. Biol. |volume=340 |issue= 4 |pages= 641–53 |year= 2004 |pmid= 15223310 |doi= 10.1016/j.jmb.2004.05.025
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Sato F, Kawamoto T, Fujimoto K, "et al." |title=Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. |journal=Eur. J. Biochem. |volume=271 |issue= 22 |pages= 4409–19 |year= 2005 |pmid= 15560782 |doi= 10.1111/j.1432-1033.2004.04379.x
*cite journal | author=Ivanova AV, Ivanov SV, Lerman ML |title=Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins. |journal=Cell. Mol. Life Sci. |volume=62 |issue= 4 |pages= 471–84 |year= 2005 |pmid= 15719173 |doi= 10.1007/s00018-004-4423-2
*cite journal | author=Ivanova A, Liao SY, Lerman MI, "et al." |title=STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker. |journal=J. Med. Genet. |volume=42 |issue= 7 |pages= 565–76 |year= 2006 |pmid= 15994878 |doi= 10.1136/jmg.2004.029835
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029

External links


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