Regulatory factor X, 2 (influences HLA class II expression), also known as RFX2, is a human gene.cite web | title = Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5990| accessdate = ]

section_title =
summary_text = This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.cite web | title = Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5990| accessdate = ]


Further reading

citations =
*cite journal | author=Pugliatti L, Derré J, Berger R, "et al." |title=The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19. |journal=Genomics |volume=13 |issue= 4 |pages= 1307–10 |year= 1992 |pmid= 1505960 |doi=
*cite journal | author=Reith W, Ucla C, Barras E, "et al." |title=RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. |journal=Mol. Cell. Biol. |volume=14 |issue= 2 |pages= 1230–44 |year= 1994 |pmid= 8289803 |doi=
*cite journal | author=Doyle J, Hoffman S, Ucla C, "et al." |title=Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins. |journal=Genomics |volume=35 |issue= 1 |pages= 227–30 |year= 1996 |pmid= 8661125 |doi= 10.1006/geno.1996.0343
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Iwama A, Pan J, Zhang P, "et al." |title=Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 3940–50 |year= 1999 |pmid= 10330134 |doi=
*cite journal | author=Morotomi-Yano K, Yano K, Saito H, "et al." |title=Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 836–42 |year= 2002 |pmid= 11682486 |doi= 10.1074/jbc.M108638200
*cite journal | author=Sengupta PK, Fargo J, Smith BD |title=The RFX family interacts at the collagen (COL1A2) start site and represses transcription. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24926–37 |year= 2002 |pmid= 11986307 |doi= 10.1074/jbc.M111712200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Maijgren S, Sur I, Nilsson M, Toftgård R |title=Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element. |journal=Arch. Dermatol. Res. |volume=295 |issue= 11 |pages= 482–9 |year= 2004 |pmid= 15024578 |doi= 10.1007/s00403-004-0456-5
*cite journal | author=Horvath GC, Kistler WS, Kistler MK |title=RFX2 is a potential transcriptional regulatory factor for histone H1t and other genes expressed during the meiotic phase of spermatogenesis. |journal=Biol. Reprod. |volume=71 |issue= 5 |pages= 1551–9 |year= 2005 |pmid= 15229132 |doi= 10.1095/biolreprod.104.032268
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

External links


update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • RFX1 — Regulatory factor X, 1 (influences HLA class II expression), also known as RFX1, is a human gene.cite web | title = Entrez Gene: RFX1 regulatory factor X, 1 (influences HLA class II expression)| url =… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.