- Retinoic acid receptor
protein
Name =retinoic acid receptor alpha
caption =
width =
HGNCid = 9864
Symbol = RARA
AltSymbols =
EntrezGene = 5914
OMIM = 180240
RefSeq = NM_000964
UniProt = P10276
PDB =
ECnumber =
Chromosome = 17
Arm = q
Band = 12
LocusSupplementaryData = protein
Name =retinoic acid receptor beta
caption =
width =
HGNCid = 9865
Symbol = RARB
AltSymbols =
EntrezGene = 5915
OMIM = 180220
RefSeq = NM_000965
UniProt = P10826
PDB =
ECnumber =
Chromosome = 3
Arm = p
Band = 24
LocusSupplementaryData = protein
Name =retinoic acid receptor gamma
caption =
width =
HGNCid = 9866
Symbol = RARG
AltSymbols =
EntrezGene = 5916
OMIM = 180190
RefSeq = NM_000966
UniProt = P13631
PDB =
ECnumber =
Chromosome = 12
Arm = q
Band = 13
LocusSupplementaryData = The retinoic acid receptor (RAR) is a type ofnuclear receptor cite journal |author=Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H|title=International Union of Pharmacology. LX. Retinoic acid receptors |journal= Pharmacol Rev |volume= 58 |issue= 4 |pages= 712–25 |year= 2006| doi = 10.1124/pr.58.4.4 |pmid= 17132850] which is activated by bothall-trans retinoic acid and9-cis retinoic acid .cite journal |author=Allenby G, Bocquel MT, Saunders M, Kazmer S, Speck J, Rosenberger M, Lovey A, Kastner P, Grippo JF, Chambon P, Levin AA|title=Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids |journal= Proc Natl Acad Sci U S A |volume= 90 |issue= 1 |pages= 30–4 |year= 1993| doi = 10.1073/pnas.90.1.30 |pmid= 8380496] There are three retinoic acid receptors (RAR), RAR-alpha, RAR-beta, and RAR-gamma encoded by the gene|RARA, gene|RARB, gene|RARG genes respectively. Each receptor isoform has several splice variants: two- for alpha, four- for beta and two- for gamma.As with other type II nuclear receptors, RAR heterodimerizes with
RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements complexed with corepressor protein. Binding of agonistligand s to RAR results in dissociation of corepressor and recruitment of coactivator protein which in turn promotes transcription of the downstream targetgene intomRNA and eventuallyprotein .ee also
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Retinoid X receptor References
External links
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