Rev-ErbA


Rev-ErbA

The Rev-ErbA proteins are members of the nuclear receptor family of intracellular transcription factors. There are two forms of the receptor, alpha and beta, each encoded by a separate gene (gene|NR1D1 and gene|NR1D2 respectively).cite journal | author = Dumas B, Harding HP, Choi HS, Lehmann KA, Chung M, Lazar MA, Moore DD | title = A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb | journal = Mol. Endocrinol. | volume = 8 | issue = 8 | pages = 996–1005 | year = 1994 | pmid = 7997240 | doi = 10.1210/me.8.8.996 | issn = ]

The rev-Erb-α gene is highly unusual in that it is encoded on the opposite strand of the alpha-thyroid hormone receptor (TR) gene.cite journal | author = Lazar MA, Jones KE, Chin WW | title = Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone | journal = DNA Cell Biol. | volume = 9 | issue = 2 | pages = 77–83 | year = 1990 | pmid = 1971514 | doi = | issn = ]

The rev-Erb-α protein is a key regulatory component of the circadian clock.cite journal | author = Yin L, Wang J, Klein PS, Lazar MA | title = Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock | journal = Science | volume = 311 | issue = 5763 | pages = 1002–5 | year = 2006 | pmid = 16484495 | doi = 10.1126/science.1121613 | issn = ] cite journal | author = Wang J, Yin L, Lazar MA | title = The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1 | journal = J. Biol. Chem. | volume = 281 | issue = 45 | pages = 33842–8 | year = 2006 | pmid = 16968709 | doi = 10.1074/jbc.M607873200 | issn = ] In addition, rev-Erb-α appears also to regulate the break down of cartilage.cite journal | author = Chaturvedi P, Pratta M, Steplewski K, Connor J, Kumar S | title = Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis | journal = Arthritis Rheum. | volume = 54 | issue = 11 | pages = 3513–22 | year = 2006 | pmid = 17075855 | doi = 10.1002/art.22170 | issn = ]

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