Interferon regulatory factor 8, also known as IRF8, is a human gene.cite web | title = Entrez Gene: IRF8 interferon regulatory factor 8| url =| accessdate = ]

section_title =
summary_text = Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.cite web | title = Entrez Gene: IRF8 interferon regulatory factor 8| url =| accessdate = ]

ee also

* Interferon regulatory factors


Further reading

citations =
*cite journal | author=Weisz A, Marx P, Sharf R, "et al." |title=Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes. |journal=J. Biol. Chem. |volume=267 |issue= 35 |pages= 25589–96 |year= 1993 |pmid= 1460054 |doi=
*cite journal | author=Sharf R, Azriel A, Lejbkowicz F, "et al." |title=Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors. |journal=J. Biol. Chem. |volume=270 |issue= 22 |pages= 13063–9 |year= 1995 |pmid= 7768900 |doi=
*cite journal | author=Holtschke T, Löhler J, Kanno Y, "et al." |title=Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. |journal=Cell |volume=87 |issue= 2 |pages= 307–17 |year= 1996 |pmid= 8861914 |doi=
*cite journal | author=Schaper F, Kirchhoff S, Posern G, "et al." |title=Functional domains of interferon regulatory factor I (IRF-1). |journal=Biochem. J. |volume=335 ( Pt 1) |issue= |pages= 147–57 |year= 1998 |pmid= 9742224 |doi=
*cite journal | author=Li W, Nagineni CN, Ge H, "et al." |title=Interferon consensus sequence-binding protein is constitutively expressed and differentially regulated in the ocular lens. |journal=J. Biol. Chem. |volume=274 |issue= 14 |pages= 9686–91 |year= 1999 |pmid= 10092656 |doi=
*cite journal | author=Li W, Nagineni CN, Hooks JJ, "et al." |title=Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors. |journal=Invest. Ophthalmol. Vis. Sci. |volume=40 |issue= 5 |pages= 976–82 |year= 1999 |pmid= 10102295 |doi=
*cite journal | author=Rehli M, Poltorak A, Schwarzfischer L, "et al." |title=PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. |journal=J. Biol. Chem. |volume=275 |issue= 13 |pages= 9773–81 |year= 2000 |pmid= 10734131 |doi=
*cite journal | author=Cohen H, Azriel A, Cohen T, "et al." |title=Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39081–9 |year= 2001 |pmid= 10991940 |doi= 10.1074/jbc.M004900200
*cite journal | author=Nehyba J, Hrdlicková R, Burnside J, Bose HR |title=A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein. |journal=Mol. Cell. Biol. |volume=22 |issue= 11 |pages= 3942–57 |year= 2002 |pmid= 11997525 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhu C, Saberwal G, Lu Y, "et al." |title=The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1. |journal=J. Biol. Chem. |volume=279 |issue= 49 |pages= 50874–85 |year= 2005 |pmid= 15371411 |doi= 10.1074/jbc.M405736200
*cite journal | author=Liu J, Guan X, Tamura T, "et al." |title=Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55609–17 |year= 2005 |pmid= 15489234 |doi= 10.1074/jbc.M406565200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, "et al." |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776
*cite journal | author=Xiong H, Li H, Kong HJ, "et al." |title=Ubiquitin-dependent degradation of interferon regulatory factor-8 mediated by Cbl down-regulates interleukin-12 expression. |journal=J. Biol. Chem. |volume=280 |issue= 25 |pages= 23531–9 |year= 2005 |pmid= 15837792 |doi= 10.1074/jbc.M414296200
*cite journal | author=Zhao J, Kong HJ, Li H, "et al." |title=IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways. |journal=J. Biol. Chem. |volume=281 |issue= 15 |pages= 10073–80 |year= 2006 |pmid= 16484229 |doi= 10.1074/jbc.M507788200
*cite journal | author=Huang W, Saberwal G, Horvath E, "et al." |title=Leukemia-associated, constitutively active mutants of SHP2 protein tyrosine phosphatase inhibit NF1 transcriptional activation by the interferon consensus sequence binding protein. |journal=Mol. Cell. Biol. |volume=26 |issue= 17 |pages= 6311–32 |year= 2006 |pmid= 16914719 |doi= 10.1128/MCB.00036-06
*cite journal | author=Dimberg A, Kårehed K, Nilsson K, Oberg F |title=Inhibition of monocytic differentiation by phosphorylation-deficient Stat1 is associated with impaired expression of Stat2, ICSBP/IRF8 and C/EBPepsilon. |journal=Scand. J. Immunol. |volume=64 |issue= 3 |pages= 271–9 |year= 2006 |pmid= 16918696 |doi= 10.1111/j.1365-3083.2006.01827.x
*cite journal | author=Peng YB, Yerle M, Liu B |title=Mapping of nine porcine interferon regulatory factor genes. |journal=Anim. Genet. |volume=37 |issue= 6 |pages= 600–1 |year= 2007 |pmid= 17121613 |doi= 10.1111/j.1365-2052.2006.01525.x
*cite journal | author=Huang W, Horvath E, Eklund EA |title=PU.1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in differentiating myeloid cells. |journal=J. Biol. Chem. |volume=282 |issue= 9 |pages= 6629–43 |year= 2007 |pmid= 17200120 |doi= 10.1074/jbc.M607760200

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