Transcription Factor II B

Transcription Factor II B

Transcription Factor II B (TFIIB) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.cite book | author = Lewin, Benjamin | title = Genes VIII | publisher = Pearson Prentice Hall | location = Upper Saddle River, NJ | year = 2004 | pages = p636-637 | isbn = 0-13-144946-X | oclc = | doi = ] It is encoded by the gene|TFIIB gene.cite journal | author = Ha I, Lane WS, Reinberg D | title = Cloning of a human gene encoding the general transcription initiation factor IIB | journal = Nature | volume = 352 | issue = 6337 | pages = 689–95 | year = 1991 | pmid = 1876184 | doi = 10.1038/352689a0 | issn = ] cite journal | author = Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC | title = Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome | journal = Hum. Mol. Genet. | volume = 3 | issue = 1 | pages = 61–4 | year = 1994 | pmid = 8162052 | doi = 10.1093/hmg/3.1.61 | issn = ]

Transcription factor IIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. The protein serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [cite web | title = Entrez Gene: GTF2B general transcription factor IIB| url =| accessdate = ] It is involved in the selection of the transcription start site: mutations in TFIIB cause a shift in the transcription start site.cite journal | author = Lee TI, Young RA | title = Transcription of eukaryotic protein-coding genes | journal = Annu. Rev. Genet. | volume = 34 | issue = | pages = 77–137 | year = 2000 | pmid = 11092823 | doi = 10.1146/annurev.genet.34.1.77]

See also



Further reading

citations =
*cite journal | author=Roeder RG |title=The role of general initiation factors in transcription by RNA polymerase II. |journal=Trends Biochem. Sci. |volume=21 |issue= 9 |pages= 327–35 |year= 1996 |pmid= 8870495 |doi=
*cite journal | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789
*cite journal | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153–67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013
*cite journal | author=Seelamgari A, Maddukuri A, Berro R, "et al." |title=Role of viral regulatory and accessory proteins in HIV-1 replication. |journal=Front. Biosci. |volume=9 |issue= |pages= 2388–413 |year= 2006 |pmid= 15353294 |doi=
*cite journal | author=Ing NH, Beekman JM, Tsai SY, "et al." |title=Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). |journal=J. Biol. Chem. |volume=267 |issue= 25 |pages= 17617–23 |year= 1992 |pmid= 1517211 |doi=
*cite journal | author=Malik S, Hisatake K, Sumimoto H, "et al." |title=Sequence of general transcription factor TFIIB and relationships to other initiation factors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 21 |pages= 9553–7 |year= 1991 |pmid= 1946368 |doi=
*cite journal | author=Klemm RD, Goodrich JA, Zhou S, Tjian R |title=Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 13 |pages= 5788–92 |year= 1995 |pmid= 7597030 |doi=
*cite journal | author=Veschambre P, Simard P, Jalinot P |title=Evidence for functional interaction between the HIV-1 Tat transactivator and the TATA box binding protein in vivo. |journal=J. Mol. Biol. |volume=250 |issue= 2 |pages= 169–80 |year= 1995 |pmid= 7608968 |doi= 10.1006/jmbi.1995.0368
*cite journal | author=Desai-Yajnik V, Hadzic E, Modlinger P, "et al." |title=Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator. |journal=J. Virol. |volume=69 |issue= 8 |pages= 5103–12 |year= 1995 |pmid= 7609079 |doi=
*cite journal | author=Cavaillès V, Dauvois S, L'Horset F, "et al." |title=Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. |journal=EMBO J. |volume=14 |issue= 15 |pages= 3741–51 |year= 1995 |pmid= 7641693 |doi=
*cite journal | author=Nakshatri H, Nakshatri P, Currie RA |title=Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter. |journal=J. Biol. Chem. |volume=270 |issue= 33 |pages= 19613–23 |year= 1995 |pmid= 7642649 |doi=
*cite journal | author=Abendroth FD, Peterson SR, Galman M, "et al." |title=Identification of human autoantibodies to transcription factor IIB. |journal=Nucleic Acids Res. |volume=23 |issue= 14 |pages= 2770–4 |year= 1995 |pmid= 7651839 |doi=
*cite journal | author=Bagby S, Kim S, Maldonado E, "et al." |title=Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein. |journal=Cell |volume=82 |issue= 5 |pages= 857–67 |year= 1995 |pmid= 7671313 |doi=
*cite journal | author=Nikolov DB, Chen H, Halay ED, "et al." |title=Crystal structure of a TFIIB-TBP-TATA-element ternary complex. |journal=Nature |volume=377 |issue= 6545 |pages= 119–28 |year= 1995 |pmid= 7675079 |doi= 10.1038/377119a0
*cite journal | author=Schmitz ML, Stelzer G, Altmann H, "et al." |title=Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivators. |journal=J. Biol. Chem. |volume=270 |issue= 13 |pages= 7219–26 |year= 1995 |pmid= 7706261 |doi=
*cite journal | author=Yu L, Zhang Z, Loewenstein PM, "et al." |title=Molecular cloning and characterization of a cellular protein that interacts with the human immunodeficiency virus type 1 Tat transactivator and encodes a strong transcriptional activation domain. |journal=J. Virol. |volume=69 |issue= 5 |pages= 3007–16 |year= 1995 |pmid= 7707527 |doi=
*cite journal | author=Yu L, Loewenstein PM, Zhang Z, Green M |title=In vitro interaction of the human immunodeficiency virus type 1 Tat transactivator and the general transcription factor TFIIB with the cellular protein TAP. |journal=J. Virol. |volume=69 |issue= 5 |pages= 3017–23 |year= 1995 |pmid= 7707528 |doi=
*cite journal | author=Auffray C, Behar G, Bois F, "et al." |title= [

*cite journal | author=Franklin CC, McCulloch AV, Kraft AS |title=In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB. |journal=Biochem. J. |volume=305 ( Pt 3) |issue= |pages= 967–74 |year= 1995 |pmid= 7848298 |doi=

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  • Transcription Factor II F — protein Name = general transcription factor IIF, polypeptide 1, 74kDa caption = width = HGNCid = 4652 Symbol = GTF2F1 AltSymbols = TFIIF, BTF4, RAP74 EntrezGene = 2962 OMIM = 189968 RefSeq = NM 002096 UniProt = P35269 PDB = ECnumber = Chromosome …   Wikipedia

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  • Transcription Factor II E — protein Name = general transcription factor IIE, polypeptide 1, alpha 56kDa caption = width = HGNCid = 4650 Symbol = GTF2E1 AltSymbols = TF2E1 EntrezGene = 2960 OMIM = 189962 RefSeq = NM 005513 UniProt = P29083 PDB = ECnumber = Chromosome = 3 Arm …   Wikipedia

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  • transcription factor — Protein required for recognition by RNA polymerases of specific stimulatory sequences in eukaryotic genes. Several are known that activate transcription by RNA polymerase II when bound to upstream promoters. Transcription of the 5S RNA gene in… …   Dictionary of molecular biology

  • transcription factor — noun Date: 1972 any of various proteins that bind to DNA and play a role in the regulation of gene expression by promoting transcription …   New Collegiate Dictionary

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