ELK1


ELK1

ELK1, member of ETS oncogene family, also known as ELK1, is a human gene.

PBB_Summary
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summary_text = This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. [cite web | title = Entrez Gene: ELK1 ELK1, member of ETS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2002| accessdate = ]

References

Further reading

*PBB_Further_reading
citations =
*cite journal | author=Sharrocks AD, Brown AL, Ling Y, Yates PR |title=The ETS-domain transcription factor family. |journal=Int. J. Biochem. Cell Biol. |volume=29 |issue= 12 |pages= 1371–87 |year= 1998 |pmid= 9570133 |doi=
*cite journal | author=Wasylyk B, Hagman J, Gutierrez-Hartmann A |title=Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway. |journal=Trends Biochem. Sci. |volume=23 |issue= 6 |pages= 213–6 |year= 1998 |pmid= 9644975 |doi=
*cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87–94 |year= 2005 |pmid= 15638726 |doi=
Rao VN, Reddy ES.Delta elk-1, a variant of elk-1, fails to interact with the serum response factor and binds to DNA with modulated specificity.Cancer Res. 1993 Jan 15;53(2):215-20.

Shao N, Chai Y, Cui JQ, Wang N, Aysola K, Reddy ES, Rao VN. Induction of apoptosis by Elk-1 and deltaElk-1 proteins.Oncogene. 1998 Jul 30;17(4):527-32.

Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, Yezdani M, Reddy ES, Rao VN.c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells.Oncogene. 2001 Mar 15;20(11):1357-67.

External links

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