Homeobox B2, also known as HOXB2, is a human gene.cite web | title = Entrez Gene: HOXB2 homeobox B2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3212| accessdate = ]

section_title =
summary_text = This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.cite web | title = Entrez Gene: HOXB2 homeobox B2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3212| accessdate = ]

ee also

* Homeobox


Further reading

citations =
*cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551–3 |year= 1992 |pmid= 1358459 |doi=
*cite journal | author=Lavelle D, Ducksworth J, Eves E, "et al." |title=A homeodomain protein binds to gamma-globin gene regulatory sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 16 |pages= 7318–22 |year= 1991 |pmid= 1871139 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Giampaolo A, Acampora D, Zappavigna V, "et al." |title=Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. |journal=Differentiation |volume=40 |issue= 3 |pages= 191–7 |year= 1989 |pmid= 2570724 |doi=
*cite journal | author=Acampora D, D'Esposito M, Faiella A, "et al." |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=
*cite journal | author=Boncinelli E, Acampora D, Pannese M, "et al." |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745–56 |year= 1990 |pmid= 2576652 |doi=
*cite journal | author=Kongsuwan K, Webb E, Housiaux P, Adams JM |title=Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages. |journal=EMBO J. |volume=7 |issue= 7 |pages= 2131–8 |year= 1988 |pmid= 2901346 |doi=
*cite journal | author=Vieille-Grosjean I, Huber P |title=Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells. |journal=J. Biol. Chem. |volume=270 |issue= 9 |pages= 4544–50 |year= 1995 |pmid= 7876223 |doi=
*cite journal | author=Guazzi S, Lonigro R, Pintonello L, "et al." |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339–47 |year= 1994 |pmid= 7913891 |doi=
*cite journal | author=Guazzi S, Pintonello ML, Viganò A, Boncinelli E |title=Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells. |journal=J. Biol. Chem. |volume=273 |issue= 18 |pages= 11092–9 |year= 1998 |pmid= 9556594 |doi=
*cite journal | author=Davenne M, Maconochie MK, Neun R, "et al." |title=Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain. |journal=Neuron |volume=22 |issue= 4 |pages= 677–91 |year= 1999 |pmid= 10230789 |doi=
*cite journal | author=Case SS, Huber P, Lloyd JA |title=The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation. |journal=DNA Cell Biol. |volume=18 |issue= 11 |pages= 805–17 |year= 2000 |pmid= 10595394 |doi= 10.1089/104454999314809
*cite journal | author=Golpon HA, Geraci MW, Moore MD, "et al." |title=HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema. |journal=Am. J. Pathol. |volume=158 |issue= 3 |pages= 955–66 |year= 2001 |pmid= 11238043 |doi=
*cite journal | author=Shen WF, Krishnan K, Lawrence HJ, Largman C |title=The HOX homeodomain proteins block CBP histone acetyltransferase activity. |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7509–22 |year= 2001 |pmid= 11585930 |doi= 10.1128/MCB.21.21.7509-7522.2001
*cite journal | author=Liu X, Zhang X |title=Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells. |journal=Chin. J. Traumatol. |volume=5 |issue= 1 |pages= 12–5 |year= 2002 |pmid= 11835749 |doi=
*cite journal | author=Kosaki K, Kosaki R, Suzuki T, "et al." |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ivins S, Pemberton K, Guidez F, "et al." |title=Regulation of Hoxb2 by APL-associated PLZF protein. |journal=Oncogene |volume=22 |issue= 24 |pages= 3685–97 |year= 2003 |pmid= 12802276 |doi= 10.1038/sj.onc.1206328
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Segara D, Biankin AV, Kench JG, "et al." |title=Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia. |journal=Clin. Cancer Res. |volume=11 |issue= 9 |pages= 3587–96 |year= 2005 |pmid= 15867264 |doi= 10.1158/1078-0432.CCR-04-1813

External links


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