ELF5


ELF5

E74-like factor 5 (ets domain transcription factor), is a gene found in both mice and humans.cite web | title = Entrez Gene: ELF5 E74-like factor 5 (ets domain transcription factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2001| accessdate = ] In humans it is also called ESE2.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: ELF5 E74-like factor 5 (ets domain transcription factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2001| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sharrocks AD, Brown AL, Ling Y, Yates PR |title=The ETS-domain transcription factor family. |journal=Int. J. Biochem. Cell Biol. |volume=29 |issue= 12 |pages= 1371–87 |year= 1998 |pmid= 9570133 |doi=
*cite journal | author=Zhou J, Ng AY, Tymms MJ, "et al." |title=A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines. |journal=Oncogene |volume=17 |issue= 21 |pages= 2719–32 |year= 1998 |pmid= 9840936 |doi= 10.1038/sj.onc.1202198
*cite journal | author=Oettgen P, Kas K, Dube A, "et al." |title=Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes. |journal=J. Biol. Chem. |volume=274 |issue= 41 |pages= 29439–52 |year= 1999 |pmid= 10506207 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lapinskas EJ, Palmer J, Ricardo S, "et al." |title=A major site of expression of the ets transcription factor Elf5 is epithelia of exocrine glands. |journal=Histochem. Cell Biol. |volume=122 |issue= 6 |pages= 521–6 |year= 2005 |pmid= 15655699 |doi= 10.1007/s00418-004-0713-x
*cite journal | author=Yaniw D, Hu J |title=Epithelium-specific ets transcription factor 2 upregulates cytokeratin 18 expression in pulmonary epithelial cells through an interaction with cytokeratin 18 intron 1. |journal=Cell Res. |volume=15 |issue= 6 |pages= 423–9 |year= 2005 |pmid= 15987600 |doi= 10.1038/sj.cr.7290310
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Tummala R, Sinha S |title=Differentiation-specific transcriptional regulation of the ESE-2 gene by a novel keratinocyte-restricted factor. |journal=J. Cell. Biochem. |volume=97 |issue= 4 |pages= 766–81 |year= 2006 |pmid= 16229011 |doi= 10.1002/jcb.20685
*cite journal | author=Taylor TD, Noguchi H, Totoki Y, "et al." |title=Human chromosome 11 DNA sequence and analysis including novel gene identification. |journal=Nature |volume=440 |issue= 7083 |pages= 497–500 |year= 2006 |pmid= 16554811 |doi= 10.1038/nature04632
*cite journal | author=Choi YS, Sinha S |title=Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2. |journal=Biochem. J. |volume=398 |issue= 3 |pages= 497–507 |year= 2006 |pmid= 16704374 |doi= 10.1042/BJ20060375
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032

External links

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