Retinoid X receptor alpha


Retinoid X receptor alpha
Retinoid X receptor, alpha

PDB rendering based on 1by4.
Identifiers
Symbols RXRA; FLJ00280; FLJ00318; FLJ16020; FLJ16733; MGC102720; NR2B1
External IDs OMIM180245 MGI98214 HomoloGene2220 IUPHAR: NR2B1 GeneCards: RXRA Gene
RNA expression pattern
PBB GE RXRA 202449 s at tn.png
PBB GE RXRA 202426 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6256 20181
Ensembl ENSG00000186350 ENSMUSG00000015846
UniProt P19793 Q3UMU4
RefSeq (mRNA) NM_002957.4 NM_011305.3
RefSeq (protein) NP_002948.1 NP_035435.1
Location (UCSC) Chr 9:
137.21 – 137.33 Mb
Chr 2:
27.53 – 27.62 Mb
PubMed search [1] [2]

Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 (nuclear receptor subfamily 2, group B, member 1) is a nuclear receptor that in humans is encoded by the RXRA gene.[1]

Contents

Function

Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcription factors.[2]

Interactions

Retinoid X receptor alpha has been shown to interact with:

See also

References

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Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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