Activating transcription factor 6, also known as ATF6, is a human gene.

section_title =
summary_text = ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules. [supplied by OMIM] cite web | title = Entrez Gene: ATF6 activating transcription factor 6| url =| accessdate = ]

ee also

* Activating transcription factor


Further reading

citations =
*cite journal | author=Hai T, Hartman MG |title=The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. |journal=Gene |volume=273 |issue= 1 |pages= 1–11 |year= 2001 |pmid= 11483355 |doi=
*cite journal | author=Hai TW, Liu F, Coukos WJ, Green MR |title=Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. |journal=Genes Dev. |volume=3 |issue= 12B |pages= 2083–90 |year= 1990 |pmid= 2516827 |doi=
*cite journal | author=Zhu C, Johansen FE, Prywes R |title=Interaction of ATF6 and serum response factor. |journal=Mol. Cell. Biol. |volume=17 |issue= 9 |pages= 4957–66 |year= 1997 |pmid= 9271374 |doi=
*cite journal | author=Yoshida H, Haze K, Yanagi H, "et al." |title=Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. |journal=J. Biol. Chem. |volume=273 |issue= 50 |pages= 33741–9 |year= 1999 |pmid= 9837962 |doi=
*cite journal | author=Haze K, Yoshida H, Yanagi H, "et al." |title=Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. |journal=Mol. Biol. Cell |volume=10 |issue= 11 |pages= 3787–99 |year= 1999 |pmid= 10564271 |doi=
*cite journal | author=Li M, Baumeister P, Roy B, "et al." |title=ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1. |journal=Mol. Cell. Biol. |volume=20 |issue= 14 |pages= 5096–106 |year= 2000 |pmid= 10866666 |doi=
*cite journal | author=Yoshida H, Okada T, Haze K, "et al." |title=Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. |journal=Mol. Cell. Biol. |volume=21 |issue= 4 |pages= 1239–48 |year= 2001 |pmid= 11158310 |doi= 10.1128/MCB.21.4.1239-1248.2001
*cite journal | author=Ye J, Rawson RB, Komuro R, "et al." |title=ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. |journal=Mol. Cell |volume=6 |issue= 6 |pages= 1355–64 |year= 2001 |pmid= 11163209 |doi=
*cite journal | author=Parker R, Phan T, Baumeister P, "et al." |title=Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: its autoregulation by stress and interaction with ATF6. |journal=Mol. Cell. Biol. |volume=21 |issue= 9 |pages= 3220–33 |year= 2001 |pmid= 11287625 |doi= 10.1128/MCB.21.9.3220-3233.2001
*cite journal | author=Gotoh T, Oyadomari S, Mori K, Mori M |title=Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12343–50 |year= 2002 |pmid= 11805088 |doi= 10.1074/jbc.M107988200
*cite journal | author=Chen X, Shen J, Prywes R |title=The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 13045–52 |year= 2002 |pmid= 11821395 |doi= 10.1074/jbc.M110636200
*cite journal | author=Thuerauf DJ, Morrison LE, Hoover H, Glembotski CC |title=Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20734–9 |year= 2002 |pmid= 11909875 |doi= 10.1074/jbc.M201749200
*cite journal | author=Okada T, Yoshida H, Akazawa R, "et al." |title=Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. |journal=Biochem. J. |volume=366 |issue= Pt 2 |pages= 585–94 |year= 2002 |pmid= 12014989 |doi= 10.1042/BJ20020391
*cite journal | author=Luo S, Lee AS |title=Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-induced phosphorylation. |journal=Biochem. J. |volume=366 |issue= Pt 3 |pages= 787–95 |year= 2002 |pmid= 12076252 |doi= 10.1042/BJ20011802
*cite journal | author=Tardif KD, Mori K, Siddiqui A |title=Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway. |journal=J. Virol. |volume=76 |issue= 15 |pages= 7453–9 |year= 2002 |pmid= 12097557 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shuda M, Kondoh N, Imazeki N, "et al." |title=Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. |journal=J. Hepatol. |volume=38 |issue= 5 |pages= 605–14 |year= 2004 |pmid= 12713871 |doi=
*cite journal | author=Okada T, Haze K, Nadanaka S, "et al." |title=A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 31024–32 |year= 2003 |pmid= 12782636 |doi= 10.1074/jbc.M300923200
*cite journal | author=Newman JR, Keating AE |title=Comprehensive identification of human bZIP interactions with coiled-coil arrays. |journal=Science |volume=300 |issue= 5628 |pages= 2097–101 |year= 2003 |pmid= 12805554 |doi= 10.1126/science.1084648

External links


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