E2F transcription factor 1, also known as E2F1, is a human gene.

section_title =
summary_text = The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [cite web | title = Entrez Gene: E2F1 E2F transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1869| accessdate = ]

ee also

* E2F


Further reading

citations =
*cite journal | author=Dupont E, Sansal I, Toru D, "et al." |title= [Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors] |journal=C. R. Seances Soc. Biol. Fil. |volume=191 |issue= 1 |pages= 95–104 |year= 1997 |pmid= 9181131 |doi=
*cite journal | author=Stevens C, La Thangue NB |title=The emerging role of E2F-1 in the DNA damage response and checkpoint control. |journal=DNA Repair (Amst.) |volume=3 |issue= 8-9 |pages= 1071–9 |year= 2005 |pmid= 15279795 |doi= 10.1016/j.dnarep.2004.03.034
*cite journal | author=Zhang Z, Wang H, Li M, "et al." |title=Novel MDM2 p53-independent functions identified through RNA silencing technologies. |journal=Ann. N. Y. Acad. Sci. |volume=1058 |issue= |pages= 205–14 |year= 2006 |pmid= 16394138 |doi= 10.1196/annals.1359.030

External links


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