Interferon regulatory factor 5, also known as IRF5, is a human gene.cite web | title = Entrez Gene: IRF5 interferon regulatory factor 5| url =| accessdate = ]

section_title =
summary_text = This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative splice variants encoding different isoforms exist.cite web | title = Entrez Gene: IRF5 interferon regulatory factor 5| url =| accessdate = ]

ee also

* Interferon regulatory factors


Further reading

citations =
*cite journal | author=Pitha PM, Au WC, Lowther W, "et al." |title=Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth. |journal=Biochimie |volume=80 |issue= 8-9 |pages= 651–8 |year= 1999 |pmid= 9865487 |doi=
*cite journal | author=Barnes B, Lubyova B, Pitha PM |title=On the role of IRF in host defense. |journal=J. Interferon Cytokine Res. |volume=22 |issue= 1 |pages= 59–71 |year= 2002 |pmid= 11846976 |doi= 10.1089/107999002753452665
*cite journal | author=Barnes BJ, Moore PA, Pitha PM |title=Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23382–90 |year= 2001 |pmid= 11303025 |doi= 10.1074/jbc.M101216200
*cite journal | author=Nehyba J, Hrdlicková R, Burnside J, Bose HR |title=A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein. |journal=Mol. Cell. Biol. |volume=22 |issue= 11 |pages= 3942–57 |year= 2002 |pmid= 11997525 |doi=
*cite journal | author=Barnes BJ, Kellum MJ, Field AE, Pitha PM |title=Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes. |journal=Mol. Cell. Biol. |volume=22 |issue= 16 |pages= 5721–40 |year= 2002 |pmid= 12138184 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Barnes BJ, Field AE, Pitha-Rowe PM |title=Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes. |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 16630–41 |year= 2003 |pmid= 12600985 |doi= 10.1074/jbc.M212609200
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Barnes BJ, Kellum MJ, Pinder KE, "et al." |title=Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death. |journal=Cancer Res. |volume=63 |issue= 19 |pages= 6424–31 |year= 2003 |pmid= 14559832 |doi=
*cite journal | author=Barnes BJ, Richards J, Mancl M, "et al." |title=Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection. |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 45194–207 |year= 2004 |pmid= 15308637 |doi= 10.1074/jbc.M400726200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lin R, Yang L, Arguello M, "et al." |title=A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization. |journal=J. Biol. Chem. |volume=280 |issue= 4 |pages= 3088–95 |year= 2005 |pmid= 15556946 |doi= 10.1074/jbc.M408452200
*cite journal | author=Sigurdsson S, Nordmark G, Göring HH, "et al." |title=Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. |journal=Am. J. Hum. Genet. |volume=76 |issue= 3 |pages= 528–37 |year= 2005 |pmid= 15657875 |doi= 10.1086/428480
*cite journal | author=Takaoka A, Yanai H, Kondo S, "et al." |title=Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. |journal=Nature |volume=434 |issue= 7030 |pages= 243–9 |year= 2005 |pmid= 15665823 |doi= 10.1038/nature03308
*cite journal | author=Schoenemeyer A, Barnes BJ, Mancl ME, "et al." |title=The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling. |journal=J. Biol. Chem. |volume=280 |issue= 17 |pages= 17005–12 |year= 2005 |pmid= 15695821 |doi= 10.1074/jbc.M412584200
*cite journal | author=Mancl ME, Hu G, Sangster-Guity N, "et al." |title=Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function. |journal=J. Biol. Chem. |volume=280 |issue= 22 |pages= 21078–90 |year= 2005 |pmid= 15805103 |doi= 10.1074/jbc.M500543200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Graham RR, Kozyrev SV, Baechler EC, "et al." |title=A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. |journal=Nat. Genet. |volume=38 |issue= 5 |pages= 550–5 |year= 2006 |pmid= 16642019 |doi= 10.1038/ng1782

External links


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