SP2 (gene)

SP2 (gene)

Sp2 transcription factor, also known as SP2, is a human gene.cite web | title = Entrez Gene: SP2 Sp2 transcription factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6668| accessdate = ]

section_title =
summary_text = This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters.cite web | title = Entrez Gene: SP2 Sp2 transcription factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6668| accessdate = ]


Further reading

citations =
*cite journal | author=Philipsen S, Suske G |title=A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. |journal=Nucleic Acids Res. |volume=27 |issue= 15 |pages= 2991–3000 |year= 1999 |pmid= 10454592 |doi=
*cite journal | author=Kingsley C, Winoto A |title=Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. |journal=Mol. Cell. Biol. |volume=12 |issue= 10 |pages= 4251–61 |year= 1992 |pmid= 1341900 |doi=
*cite journal | author=Nomura N, Nagase T, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–9 |year= 1995 |pmid= 7584044 |doi=
*cite journal | author=Scohy S, Van Vooren P, Szpirer C, Szpirer J |title=Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31-->q32.1 (Sp2), 3q24-->q31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3-->q22 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=81 |issue= 3-4 |pages= 273–4 |year= 1998 |pmid= 9730617 |doi=
*cite journal | author=Rotheneder H, Geymayer S, Haidweger E |title=Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter. |journal=J. Mol. Biol. |volume=293 |issue= 5 |pages= 1005–15 |year= 2000 |pmid= 10547281 |doi= 10.1006/jmbi.1999.3213
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Moorefield KS, Fry SJ, Horowitz JM |title=Sp2 DNA binding activity and trans-activation are negatively regulated in mammalian cells. |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 13911–24 |year= 2004 |pmid= 14726517 |doi= 10.1074/jbc.M313589200
*cite journal | author=Phan D, Cheng CJ, Galfione M, "et al." |title=Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis. |journal=Cancer Res. |volume=64 |issue= 9 |pages= 3072–8 |year= 2004 |pmid= 15126343 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Phillips RJ, Tyson-Capper Née Pollard AJ, Bailey J, "et al." |title=Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 6 |pages= 3479–90 |year= 2005 |pmid= 15788387 |doi= 10.1210/jc.2004-1962
*cite journal | author=Lee YC, Higashi Y, Luu C, "et al." |title=Sp1 elements in SULT2B1b promoter and 5'-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition. |journal=FEBS Lett. |volume=579 |issue= 17 |pages= 3639–45 |year= 2005 |pmid= 15953604 |doi= 10.1016/j.febslet.2005.05.041
*cite journal | author=Simmons SO, Horowitz JM |title=Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells. |journal=Biochem. J. |volume=393 |issue= Pt 1 |pages= 397–409 |year= 2006 |pmid= 16201967 |doi= 10.1042/BJ20051030
*cite journal | author=Moorefield KS, Yin H, Nichols TD, "et al." |title=Sp2 localizes to subnuclear foci associated with the nuclear matrix. |journal=Mol. Biol. Cell |volume=17 |issue= 4 |pages= 1711–22 |year= 2006 |pmid= 16467376 |doi= 10.1091/mbc.E05-11-1063
*cite journal | author=Das A, Fernandez-Zapico ME, Cao S, "et al." |title=Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration. |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39105–13 |year= 2007 |pmid= 17071613 |doi= 10.1074/jbc.M607720200

External links


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