PBX1


PBX1
Pre-B-cell leukemia homeobox 1

Cartoon diagram of a HOXB1–PBX1 heterodimer (violet) binding a DNA fragment (blue). Rendering based on PDB 1b72.
Identifiers
Symbols PBX1; DKFZp686B09108; MGC126627
External IDs OMIM176310 MGI97495 HomoloGene20574 GeneCards: PBX1 Gene
RNA expression pattern
PBB GE PBX1 205253 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5087 18514
Ensembl ENSG00000185630 ENSMUSG00000052534
UniProt P40424 n/a
RefSeq (mRNA) NM_001204961.1 NM_008783
RefSeq (protein) NP_001191890.1 NP_032809
Location (UCSC) Chr 1:
164.52 – 164.85 Mb
Chr 1:
170.05 – 170.36 Mb
PubMed search [1] [2]

Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene.[1]


Contents

Interactions

PBX1 has been shown to interact with HOXB1,[2][3] MEIS1[4][5][6] and HOXB7.[7]

References

  1. ^ "Entrez Gene: PBX1 Pre-B-cell leukemia homeobox 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5087. 
  2. ^ Berthelsen, J; Zappavigna V, Ferretti E, Mavilio F, Blasi F (Mar. 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". EMBO J. (ENGLAND) 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. ISSN 0261-4189. PMC 1170491. PMID 9482740. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170491. 
  3. ^ Piper, D E; Batchelor A H, Chang C P, Cleary M L, Wolberger C (Feb. 1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell (UNITED STATES) 96 (4): 587–97. doi:10.1016/S0092-8674(00)80662-5. ISSN 0092-8674. PMID 10052460. 
  4. ^ Shen, W F; Rozenfeld S, Kwong A, Köm ves L G, Lawrence H J, Largman C (Apr. 1999). "HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells". Mol. Cell. Biol. (UNITED STATES) 19 (4): 3051–61. ISSN 0270-7306. PMC 84099. PMID 10082572. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84099. 
  5. ^ Shanmugam, K; Green N C, Rambaldi I, Saragovi H U, Featherstone M S (Nov. 1999). "PBX and MEIS as Non-DNA-Binding Partners in Trimeric Complexes with HOX Proteins". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7577–88. ISSN 0270-7306. PMC 84774. PMID 10523646. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84774. 
  6. ^ Jacobs, Y; Schnabel C A, Cleary M L (Jul. 1999). "Trimeric Association of Hox and TALE Homeodomain Proteins Mediates Hoxb2 Hindbrain Enhancer Activity". Mol. Cell. Biol. (UNITED STATES) 19 (7): 5134–42. ISSN 0270-7306. PMC 84356. PMID 10373562. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84356. 
  7. ^ Chang, C P; Shen W F, Rozenfeld S, Lawrence H J, Largman C, Cleary M L (Mar. 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. (UNITED STATES) 9 (6): 663–74. doi:10.1101/gad.9.6.663. ISSN 0890-9369. PMID 7729685. 

Further reading

External links


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