MNT (gene)

MNT (gene)

MAX binding protein, also known as MNT, is a human gene.cite web | title = Entrez Gene: MNT MAX binding protein| url =| accessdate = ]

section_title =
summary_text = The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.cite web | title = Entrez Gene: MNT MAX binding protein| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Meroni G, Reymond A, Alcalay M, "et al." |title=Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. |journal=EMBO J. |volume=16 |issue= 10 |pages= 2892–906 |year= 1997 |pmid= 9184233 |doi= 10.1093/emboj/16.10.2892
*cite journal | author=Hirotsune S, Pack SD, Chong SS, "et al." |title=Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human region. |journal=Genome Res. |volume=7 |issue= 6 |pages= 625–34 |year= 1997 |pmid= 9199935 |doi=
*cite journal | author=Nigro CL, Venesio T, Reymond A, "et al." |title=The human ROX gene: genomic structure and mutation analysis in human breast tumors. |journal=Genomics |volume=49 |issue= 2 |pages= 275–82 |year= 1998 |pmid= 9598315 |doi= 10.1006/geno.1998.5241
*cite journal | author=Meroni G, Cairo S, Merla G, "et al." |title=Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? |journal=Oncogene |volume=19 |issue= 29 |pages= 3266–77 |year= 2000 |pmid= 10918583 |doi= 10.1038/sj.onc.1203634
*cite journal | author=Cairo S, Merla G, Urbinati F, "et al." |title=WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network. |journal=Hum. Mol. Genet. |volume=10 |issue= 6 |pages= 617–27 |year= 2001 |pmid= 11230181 |doi=
*cite journal | author=Stoneley M, Spencer JP, Wright SC |title=An internal ribosome entry segment in the 5' untranslated region of the mnt gene. |journal=Oncogene |volume=20 |issue= 7 |pages= 893–7 |year= 2001 |pmid= 11314024 |doi= 10.1038/sj.onc.1204157
*cite journal | author=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021–8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Smith AG, Popov N, Imreh M, "et al." |title=Expression and DNA-binding activity of MYCN/Max and Mnt/Max during induced differentiation of human neuroblastoma cells. |journal=J. Cell. Biochem. |volume=92 |issue= 6 |pages= 1282–95 |year= 2005 |pmid= 15258910 |doi= 10.1002/jcb.20121
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2
*cite journal | author=Guo XL, Pan L, Zhang XJ, "et al." |title=Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia. |journal=Leuk. Lymphoma |volume=48 |issue= 6 |pages= 1200–7 |year= 2007 |pmid= 17577784 |doi= 10.1080/10428190701342018

External links


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