Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha), also known as TFAP2A, is a human gene.cite web | title = Entrez Gene: TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)| url =| accessdate = ]

section_title =
summary_text = AP2-alpha is a 52-kD retinoic acid-inducible and developmentally regulated activator of transcription that binds to a consensus DNA-binding sequence CCCCAGGC in the SV40 and metallothionein (MIM 156350) promoters. [supplied by OMIM] cite web | title = Entrez Gene: TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)| url =| accessdate = ]

ee also

* Activating protein 2


Further reading

citations =
*cite journal | author=Murphy JE, Keen JH |title=Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia. |journal=J. Biol. Chem. |volume=267 |issue= 15 |pages= 10850–5 |year= 1992 |pmid= 1587861 |doi=
*cite journal | author=Gaynor RB, Muchardt C, Xia YR, "et al." |title=Localization of the gene for the DNA-binding protein AP-2 to human chromosome 6p22.3-pter. |journal=Genomics |volume=10 |issue= 4 |pages= 1100–2 |year= 1991 |pmid= 1916817 |doi=
*cite journal | author=Williams T, Tjian R |title=Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins. |journal=Science |volume=251 |issue= 4997 |pages= 1067–71 |year= 1991 |pmid= 1998122 |doi=
*cite journal | author=Williams T, Tjian R |title=Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. |journal=Genes Dev. |volume=5 |issue= 4 |pages= 670–82 |year= 1991 |pmid= 2010091 |doi=
*cite journal | author=Williams T, Admon A, Lüscher B, Tjian R |title=Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. |journal=Genes Dev. |volume=2 |issue= 12A |pages= 1557–69 |year= 1989 |pmid= 3063603 |doi=
*cite journal | author=Bauer R, Imhof A, Pscherer A, "et al." |title=The genomic structure of the human AP-2 transcription factor. |journal=Nucleic Acids Res. |volume=22 |issue= 8 |pages= 1413–20 |year= 1994 |pmid= 8190633 |doi=
*cite journal | author=Buettner R, Kannan P, Imhof A, "et al." |title=An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2. |journal=Mol. Cell. Biol. |volume=13 |issue= 7 |pages= 4174–85 |year= 1993 |pmid= 8321221 |doi=
*cite journal | author=Williamson JA, Bosher JM, Skinner A, "et al." |title=Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors. |journal=Genomics |volume=35 |issue= 1 |pages= 262–4 |year= 1996 |pmid= 8661133 |doi= 10.1006/geno.1996.0351
*cite journal | author=Pirozzi G, McConnell SJ, Uveges AJ, "et al." |title=Identification of novel human WW domain-containing proteins by cloning of ligand targets. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14611–6 |year= 1997 |pmid= 9169421 |doi=
*cite journal | author=Batsché E, Muchardt C, Behrens J, "et al." |title=RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2. |journal=Mol. Cell. Biol. |volume=18 |issue= 7 |pages= 3647–58 |year= 1998 |pmid= 9632747 |doi=
*cite journal | author=Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH |title=A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32957–65 |year= 1999 |pmid= 9830047 |doi=
*cite journal | author=García MA, Campillos M, Marina A, "et al." |title=Transcription factor AP-2 activity is modulated by protein kinase A-mediated phosphorylation. |journal=FEBS Lett. |volume=444 |issue= 1 |pages= 27–31 |year= 1999 |pmid= 10037142 |doi=
*cite journal | author=Rosenthal JA, Chen H, Slepnev VI, "et al." |title=The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. |journal=J. Biol. Chem. |volume=274 |issue= 48 |pages= 33959–65 |year= 1999 |pmid= 10567358 |doi=
*cite journal | author=Heicklen-Klein A, Ginzburg I |title=Tau promoter confers neuronal specificity and binds Sp1 and AP-2. |journal=J. Neurochem. |volume=75 |issue= 4 |pages= 1408–18 |year= 2000 |pmid= 10987820 |doi=
*cite journal | author=Nyormoi O, Wang Z, Doan D, "et al." |title=Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells. |journal=Mol. Cell. Biol. |volume=21 |issue= 15 |pages= 4856–67 |year= 2001 |pmid= 11438643 |doi= 10.1128/MCB.21.15.4856-4867.2001
*cite journal | author=Rao DS, Chang JC, Kumar PD, "et al." |title=Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors. |journal=Mol. Cell. Biol. |volume=21 |issue= 22 |pages= 7796–806 |year= 2001 |pmid= 11604514 |doi= 10.1128/MCB.21.22.7796-7806.2001
*cite journal | author=Bragança J, Swingler T, Marques FI, "et al." |title=Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8559–65 |year= 2002 |pmid= 11744733 |doi= 10.1074/jbc.M110850200
*cite journal | author=Mertens PR, Steinmann K, Alfonso-Jaume MA, "et al." |title=Combinatorial interactions of p53, activating protein-2, and YB-1 with a single enhancer element regulate gelatinase A expression in neoplastic cells. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24875–82 |year= 2002 |pmid= 11973333 |doi= 10.1074/jbc.M200445200
*cite journal | author=Eloranta JJ, Hurst HC |title=Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30798–804 |year= 2002 |pmid= 12072434 |doi= 10.1074/jbc.M202780200
*cite journal | author=Ben-Zimra M, Koler M, Orly J |title=Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element. |journal=Mol. Endocrinol. |volume=16 |issue= 8 |pages= 1864–80 |year= 2003 |pmid= 12145340 |doi=

External links


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