Jun D proto-oncogene, also known as JUND, is a human gene.

section_title =
summary_text = The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage results in the production of different isoforms.cite web | title = Entrez Gene: JUND jun D proto-oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3727| accessdate = ]

ee also

* AP-1 (transcription factor)


Further reading

citations =
*cite journal | author=Mollinedo F, Vaquerizo MJ, Naranjo JR |title=Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes. |journal=Biochem. J. |volume=273(Pt 2) |issue= |pages= 477–9 |year= 1991 |pmid= 1899335 |doi=
*cite journal | author=Berger I, Shaul Y |title=Structure and function of human jun-D. |journal=Oncogene |volume=6 |issue= 4 |pages= 561–6 |year= 1991 |pmid= 1903194 |doi=
*cite journal | author=Nomura N, Ide M, Sasamoto S, "et al." |title=Isolation of human cDNA clones of jun-related genes, jun-B and jun-D. |journal=Nucleic Acids Res. |volume=18 |issue= 10 |pages= 3047–8 |year= 1990 |pmid= 2112242 |doi=
*cite journal | author=Franklin CC, McCulloch AV, Kraft AS |title=In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB. |journal=Biochem. J. |volume=305 ( Pt 3) |issue= |pages= 967–74 |year= 1995 |pmid= 7848298 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Chu HM, Tan Y, Kobierski LA, "et al." |title=Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression. |journal=Mol. Endocrinol. |volume=8 |issue= 1 |pages= 59–68 |year= 1994 |pmid= 8152431 |doi=
*cite journal | author=Trask B, Fertitta A, Christensen M, "et al." |title=Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. |journal=Genomics |volume=15 |issue= 1 |pages= 133–45 |year= 1993 |pmid= 8432525 |doi=
*cite journal | author=Dorsey MJ, Tae HJ, Sollenberger KG, "et al." |title=B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. |journal=Oncogene |volume=11 |issue= 11 |pages= 2255–65 |year= 1996 |pmid= 8570175 |doi=
*cite journal | author=Claret FX, Hibi M, Dhut S, "et al." |title=A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. |journal=Nature |volume=383 |issue= 6599 |pages= 453–7 |year= 1996 |pmid= 8837781 |doi= 10.1038/383453a0
*cite journal | author=Kallunki T, Deng T, Hibi M, Karin M |title=c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. |journal=Cell |volume=87 |issue= 5 |pages= 929–39 |year= 1997 |pmid= 8945519 |doi=
*cite journal | author=Aronheim A, Zandi E, Hennemann H, "et al." |title=Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. |journal=Mol. Cell. Biol. |volume=17 |issue= 6 |pages= 3094–102 |year= 1997 |pmid= 9154808 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Labudova O, Krapfenbauer K, Moenkemann H, "et al." |title=Decreased transcription factor junD in brains of patients with Down syndrome. |journal=Neurosci. Lett. |volume=252 |issue= 3 |pages= 159–62 |year= 1998 |pmid= 9739985 |doi=
*cite journal | author=Venugopal R, Jaiswal AK |title=Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. |journal=Oncogene |volume=17 |issue= 24 |pages= 3145–56 |year= 1999 |pmid= 9872330 |doi= 10.1038/sj.onc.1202237
*cite journal | author=Agarwal SK, Guru SC, Heppner C, "et al." |title=Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. |journal=Cell |volume=96 |issue= 1 |pages= 143–52 |year= 1999 |pmid= 9989505 |doi=
*cite journal | author=Liberati NT, Datto MB, Frederick JP, "et al." |title=Smads bind directly to the Jun family of AP-1 transcription factors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 9 |pages= 4844–9 |year= 1999 |pmid= 10220381 |doi=
*cite journal | author=Gobl AE, Berg M, Lopez-Egido JR, "et al." |title=Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism. |journal=Biochim. Biophys. Acta |volume=1447 |issue= 1 |pages= 51–6 |year= 1999 |pmid= 10500243 |doi=
*cite journal | author=Ubeda M, Vallejo M, Habener JF |title=CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7589–99 |year= 1999 |pmid= 10523647 |doi=
*cite journal | author=Miyamoto NG, Medberry PS, Hesselgesser J, "et al." |title=Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors. |journal=J. Neuroimmunol. |volume=105 |issue= 1 |pages= 78–90 |year= 2000 |pmid= 10713367 |doi=
*cite journal | author=Sharma SC, Richards JS |title=Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33718–28 |year= 2000 |pmid= 10934195 |doi= 10.1074/jbc.M003555200

External links


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