Distal-less homeobox 5

PDB rendering based on 2djn.
Symbols DLX5;
External IDs OMIM600028 MGI101926 HomoloGene3825 GeneCards: DLX5 Gene
RNA expression pattern
PBB GE DLX5 213707 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1749 13395
Ensembl ENSG00000105880 ENSMUSG00000029755
UniProt P56178 Q3TYA7
RefSeq (mRNA) NM_005221 NM_010056
RefSeq (protein) NP_005212 NP_034186
Location (UCSC) Chr 7:
96.65 – 96.65 Mb
Chr 6:
6.83 – 6.83 Mb
PubMed search [1] [2]

Homeobox protein DLX-5 is a protein that in humans is encoded by the DLX5 gene.[1][2]

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less (Dll) gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.[2]



DLX5 has been shown to interact with DLX2,[3] MSX1[3] and Msh homeobox 2.[3]


  1. ^ Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K, et al. (Apr 1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc Natl Acad Sci U S A 91 (6): 2250–4. doi:10.1073/pnas.91.6.2250. PMC 43348. PMID 7907794. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=43348. 
  2. ^ a b "Entrez Gene: DLX5 distal-less homeobox 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1749. 
  3. ^ a b c Zhang, H; Hu G, Wang H, Sciavolino P, Iler N, Shen M M, Abate-Shen C (May. 1997). "Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism". Mol. Cell. Biol. (UNITED STATES) 17 (5): 2920–32. ISSN 0270-7306. PMC 232144. PMID 9111364. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232144. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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