ELK3, ETS-domain protein (SRF accessory protein 2), also known as ELK3, is a human gene.cite web | title = Entrez Gene: ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2004| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.cite web | title = Entrez Gene: ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2004| accessdate = ]


Further reading

citations =
*cite journal | author=Sharrocks AD, Brown AL, Ling Y, Yates PR |title=The ETS-domain transcription factor family. |journal=Int. J. Biochem. Cell Biol. |volume=29 |issue= 12 |pages= 1371–87 |year= 1998 |pmid= 9570133 |doi=
*cite journal | author=Wasylyk B, Hagman J, Gutierrez-Hartmann A |title=Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway. |journal=Trends Biochem. Sci. |volume=23 |issue= 6 |pages= 213–6 |year= 1998 |pmid= 9644975 |doi=
*cite journal | author=Price MA, Rogers AE, Treisman R |title=Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET). |journal=EMBO J. |volume=14 |issue= 11 |pages= 2589–601 |year= 1995 |pmid= 7540136 |doi=
*cite journal | author=Shipley J, Sheer D, Dalton S, "et al." |title=Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively. |journal=Genomics |volume=23 |issue= 3 |pages= 710–1 |year= 1995 |pmid= 7851904 |doi= 10.1006/geno.1994.1564
*cite journal | author=Giovane A, Pintzas A, Maira SM, "et al." |title=Net, a new ets transcription factor that is activated by Ras. |journal=Genes Dev. |volume=8 |issue= 13 |pages= 1502–13 |year= 1994 |pmid= 7958835 |doi=
*cite journal | author=Maira SM, Wurtz JM, Wasylyk B |title=Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif. |journal=EMBO J. |volume=15 |issue= 21 |pages= 5849–65 |year= 1997 |pmid= 8918463 |doi=
*cite journal | author=Criqui-Filipe P, Ducret C, Maira SM, Wasylyk B |title=Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation. |journal=EMBO J. |volume=18 |issue= 12 |pages= 3392–403 |year= 1999 |pmid= 10369679 |doi= 10.1093/emboj/18.12.3392
*cite journal | author=Ducret C, Maira SM, Dierich A, Wasylyk B |title=The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 7076–87 |year= 2000 |pmid= 10490644 |doi=
*cite journal | author=Ducret C, Maira SM, Lutz Y, Wasylyk B |title=The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades. |journal=Oncogene |volume=19 |issue= 44 |pages= 5063–72 |year= 2000 |pmid= 11042694 |doi= 10.1038/sj.onc.1203892
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gupta M, Sueblinvong V, Raman J, "et al." |title=Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure. |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44935–48 |year= 2004 |pmid= 12933792 |doi= 10.1074/jbc.M307696200
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wasylyk C, Criqui-Filipe P, Wasylyk B |title=Sumoylation of the net inhibitory domain (NID) is stimulated by PIAS1 and has a negative effect on the transcriptional activity of Net. |journal=Oncogene |volume=24 |issue= 5 |pages= 820–8 |year= 2005 |pmid= 15580297 |doi= 10.1038/sj.onc.1208226
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

External links


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